Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Kanemitsu, F.; Kageoka, T.; Kira, S.
    Mitochondrial creatine kinase with atypical pI values detected in serum of a patient with ovarian hepatoid yolk sac tumor (2003), J. Chromatogr. B, 783, 191-197.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.3.2 iodoacetamide 70.9% inhibition of the atypical ubiquitous mitochondrial enzyme, 74.6% inhibition of the typical ubiquitous mitochondrial enzyme Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.3.2 0.69
-
 Creatine 37°C, atypical ubiquitous mitochondrial enzyme Homo sapiens
2.7.3.2 0.74
-
 Creatine 37°C, typical ubiquitous mitochondrial enzyme Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.3.2 mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.3.2 ATP + creatine Homo sapiens
-
 ADP + phosphocreatine
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.7.3.2 Homo sapiens
-
 2 typical mitochondrial enzyme types, the sarcomeric and the ubiquitous, encoded by 2 different genes
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.3.2 typical ubiquitous mitochondrial enzyme from heart muscle tissue, atypical ubiquitous mitochondrial from serum Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.3.2 heart
-
 Homo sapiens
-
2.7.3.2 serum patient with ovarian hepatoid yolk sac tumor, an atypical ubiquitous mitochondrial enzyme form Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.3.2 ATP + creatine
-
 Homo sapiens ADP + phosphocreatine
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.7.3.2 creatine N-phosphotransferase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.3.2 37
-
 assay at Homo sapiens

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.7.3.2 45
-
 20 min, 88.1% remaining activity of the atypical ubiquitous mitochondrial enzyme, 89.6% remaining activity of the typical ubiquitous mitochondrial enzyme Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.7.3.2 5 9
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.3.2 ATP
-
 Homo sapiens

pI Value

EC Number Organism Comment pI Value Maximum pI Value
2.7.3.2 Homo sapiens the enzyme from serum of a patient with ovarian hepatoid yolk sac tumor shows an atypical pI value compared to enzyme from other, healthy tissue, overview
-
 additional information
2.7.3.2 Homo sapiens several bands in serum of a patient with ovarian hepatoid yolk sac tumor, atypical ubiquitous mitochondrial enzyme, isoelectric focusing
-
 6.8
2.7.3.2 Homo sapiens ubiquitous mitochondrial enzyme, 2 bands at pH 6.9 and pH 7.0 in isoelectric focusing
-
 6.9
2.7.3.2 Homo sapiens ubiquitous mitochondrial enzyme, 2 bands at pH 6.9 and pH 7.0 in isoelectric focusing
-
 7
2.7.3.2 Homo sapiens several bands in serum of a patient with ovarian hepatoid yolk sac tumor, atypical ubiquitous mitochondrial enzyme, isoelectric focusing 7.8 7