Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • West, G.A.; Meno, J.R.; Nguyen, T.S.; Ngai, A.C.; Simard, J.M.; Winn, H.R.
    cGMP-dependent and not cAMP-dependent kinase is required for adenosine-induced dilation of intracerebral arterioles (2003), J. Cardiovasc. Pharmacol., 41, 444-451.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.11 8-bromo-cAMP
-
 Rattus norvegicus
2.7.11.11 cAMP
-
 Rattus norvegicus
2.7.11.11 forskolin
-
 Rattus norvegicus
2.7.11.11 additional information no enzyme activation or induction by adenosine Rattus norvegicus
2.7.11.12 8-Br-cGMP selective for PKG Rattus norvegicus
2.7.11.12 adenosine adenosine-induced vasodilation in cerebral microvessesls involves cGMP and cGMP-dependent protein kinase Rattus norvegicus
2.7.11.12 cGMP selective for PKG Rattus norvegicus
2.7.11.12 cgs-21680
-
 Rattus norvegicus
2.7.11.12 sodium nitroprusside i.e. SNP, selective for PKG Rattus norvegicus
2.7.11.12 Sp-8-pCPT-cGMPS cyclic guanosine monophosphate-dependent protein kinase activator, selective for PKG Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.11 Rp-8-CPT-cAMPS
-
 Rattus norvegicus
2.7.11.12 1H-[1,2,4]oxadiazolo-[4,3-a]quinoxalin-1-one
-
 Rattus norvegicus
2.7.11.12 N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide
-
 Rattus norvegicus
2.7.11.12 Rp-8-pCTP-cGMPS selective for PKG Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.11 Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.11 additional information Rattus norvegicus the enzyme is not required for adenosine-induced dilation of intracerebral arterioles and regulation of cerebral blood flow ?
-
 ?
2.7.11.12 additional information Rattus norvegicus the enzyme is required for adenosine-induced dilation of intracerebral arterioles and thus in regulation of cerebral blood flow, mechanism ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.11 Rattus norvegicus
-
 male sprague-dawley rats
-
2.7.11.12 Rattus norvegicus
-
 male sprague-dawley rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.11 arteriole cerebral, microvascular, isolated from cortical vessels Rattus norvegicus
-
2.7.11.12 arteriole cerebral, microvascular, isolated from cortical vessels Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.11.12 additional information
-
 activity in vasodilation of arterioles measured in passive diameter Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.11 additional information the enzyme is not required for adenosine-induced dilation of intracerebral arterioles and regulation of cerebral blood flow Rattus norvegicus ?
-
 ?
2.7.11.12 additional information the enzyme is required for adenosine-induced dilation of intracerebral arterioles and thus in regulation of cerebral blood flow, mechanism Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.11 PKA
-
 Rattus norvegicus
2.7.11.12 PKG
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.12 37
-
 in vivo assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.12 6.8 7.6 assay at, study of pH responsiveness of asteriole enzymes in vivo Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.11 ATP
-
 Rattus norvegicus
2.7.11.12 ATP
-
 Rattus norvegicus