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Literature summary extracted from

  • Mashek, D.G.; McKenzie, M.A.; Van Horn, C.G.; Coleman, R.A.
    Rat long chain acyl-CoA synthetase 5 increases fatty acid uptake and partitioning to cellular triacylglcyerol in McArdle-RH7777 cells (2005), J. Biol. Chem., 281, 945-950.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.2.1.3 Triacsin C ACSL activity is 17fold higher in the presence of 0.02 mM triacsin C Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.2.1.3 ectopical overexpression of ACSL5 in rat hepatoma McArdle-RH7777 cells Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.2.1.3 endoplasmic reticulum Ad-ACSL-5, long chain acyl-CoA synthetase 5 overexpressed in rat hepatoma McRrdle-RG7777 cells mediated by adenovirus colocalizes to both mitochondria and endoplasmic reticulum Rattus norvegicus 5783
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6.2.1.3 mitochondrion
-
 Rattus norvegicus 5739
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6.2.1.3 mitochondrion ACSl5 is the only isoform of long chain acyl-CoA synthetase partly located on mitochondria. Ad-ACSL-5, long chain acyl-CoA synthetase 5 overexpressed in rat hepatoma McRrdle-RG7777 cells mediated by adenovirus colocalizes to both mitochondria and endoplasmic reticulum Rattus norvegicus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.3 Rattus norvegicus
-
-
-
6.2.1.3 Rattus norvegicus O88813
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.3 hepatoma cell
-
 Rattus norvegicus
-
6.2.1.3 McA-RH7777 cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.3 ATP + oleate + CoA
-
 Rattus norvegicus AMP + diphosphate + oleoyl-CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.2.1.3 ACSL5
-
 Rattus norvegicus
6.2.1.3 long chain acyl-CoA synthetase 5
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
6.2.1.3 ATP
-
 Rattus norvegicus