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Literature summary extracted from

  • Ridsdale, R.; Tseu, I.; Roth-Kleiner, M.; Wang, J.; Post, M.
    Increased phosphatidylcholine production but disrupted glycogen metabolism in fetal type II cells of mice that overexpress CTP:phosphocholine cytidylyltransferase (2004), J. Biol. Chem., 279, 55946-55957.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.7.15 Lipids regulation of activity by reversible association with membrane lipids Mus musculus
2.7.7.15 Lipids regulation of activity by reversible association with membrane lipids Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.15 full length enzyme and various truncated enzymes expressed in transgenic mice Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.15 membrane enzyme is activated when bound to vesicles Mus musculus 16020
-
2.7.7.15 membrane enzyme is activated when bound to vesicles Rattus norvegicus 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.15 CTP + choline phosphate Mus musculus rate limiting enzyme for the synthesis of phosphatidylcholine diphosphate + CDP-choline
-
 ?
2.7.7.15 CTP + choline phosphate Rattus norvegicus rate limiting enzyme for the synthesis of phosphatidylcholine diphosphate + CDP-choline
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.15 Mus musculus
-
-
-
2.7.7.15 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.7.15 phosphoprotein 16 serine and 2 tyrosine residues available for phosphorylation, phosphorylation is associated with decreased membrane binding and therefore, decreased activity Mus musculus
2.7.7.15 phosphoprotein 16 serine and 2 tyrosine residues available for phosphorylation, phosphorylation is associated with decreased membrane binding and therefore, decreased activity Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.15 lung
-
 Mus musculus
-
2.7.7.15 lung
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.15 CTP + choline phosphate
-
 Mus musculus diphosphate + CDP-choline
-
 ?
2.7.7.15 CTP + choline phosphate
-
 Rattus norvegicus diphosphate + CDP-choline
-
 ?
2.7.7.15 CTP + choline phosphate rate limiting enzyme for the synthesis of phosphatidylcholine Mus musculus diphosphate + CDP-choline
-
 ?
2.7.7.15 CTP + choline phosphate rate limiting enzyme for the synthesis of phosphatidylcholine Rattus norvegicus diphosphate + CDP-choline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.15 More four isoforms, CCTalpha ubiquitously expressed, whereas CCTbeta 1,-2, and -3 restricted in distribution Mus musculus
2.7.7.15 More four isoforms, CCTalpha ubiquitously expressed, whereas CCTbeta 1,-2, and -3 restricted in distribution Rattus norvegicus