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Literature summary extracted from

  • Muller, E.A.; Danner, D.J.
    Tissue-specific translation of murine branched-chain alpha-ketoacid dehydrogenase kinase mRNA is dependent upon an upstream open reading frame in the 5'-untranslated region (2004), J. Biol. Chem., 279, 44645-44655.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.4 additional information tissue-specific translation of branched-chain alpha-ketoacid dehydrogenase kinase mRNA is dependent upon an upstream open reading frame in the 5'-untranslated region Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.4 DNA sequence determination and analysis, promotor region footprinting, expression analysis, mechanism of the enzyme expression regulation Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.4 mitochondrion
-
 Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.4 ATP + branched-chain alpha-keto acid decarboxylase/dehydrogenase Mus musculus the catalyzed reversible specific phosphorylation of the BCKD subunit regulates the first committed step in the pathway for leucine, isoleucine, and valine catabolism ADP + phosphorylated branched-chain alpha-keto acid decarboxylase/dehydrogenase
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.4 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.4 BNL CL.2 cell liver cell line Mus musculus
-
2.7.11.4 C2C12 cell undifferentiated myoblast cell line Mus musculus
-
2.7.11.4 fibroblast
-
 Mus musculus
-
2.7.11.4 liver
-
 Mus musculus
-
2.7.11.4 additional information tissue distribution, tissue-specific translation of branched-chain alpha-ketoacid dehydrogenase kinase mRNA is dependent upon an upstream open reading frame in the 5'-untranslated region, thus mRNA and protein level do not correlate Mus musculus
-
2.7.11.4 myoblast
-
 Mus musculus
-
2.7.11.4 myotube
-
 Mus musculus
-
2.7.11.4 NIH-3T3 cell fibroblast cell line Mus musculus
-
2.7.11.4 skeletal muscle
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.4 ATP + branched-chain alpha-keto acid decarboxylase/dehydrogenase
-
 Mus musculus ADP + phosphorylated branched-chain alpha-keto acid decarboxylase/dehydrogenase
-
 ?
2.7.11.4 ATP + branched-chain alpha-keto acid decarboxylase/dehydrogenase the catalyzed reversible specific phosphorylation of the BCKD subunit regulates the first committed step in the pathway for leucine, isoleucine, and valine catabolism Mus musculus ADP + phosphorylated branched-chain alpha-keto acid decarboxylase/dehydrogenase
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.4 BCKD kinase
-
 Mus musculus
2.7.11.4 branched-chain alpha-ketoacid dehydrogenase kinase
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.4 ATP
-
 Mus musculus