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Literature summary extracted from

  • Constantinescu, A.; Wu, M.; Asher, O.; Diamond, I.
    cAMP-dependent protein kinase type I regulates ethanol-induced cAMP response element-mediated gene expression via activation of CREB-binding protein and inhibition of MAPK (2004), J. Biol. Chem., 279, 43321-43329.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.11 cAMP dependent on Mus musculus
2.7.11.11 additional information phosphorylation of CBP by PKA type I is induced by forskolin and ethanol, inhibition of MAPK activates the PKA type I Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.11 cytoplasm activated type I PKA is not translocated to the nucleus Mus musculus 5737
-
2.7.11.11 nucleus activated type II PKA is translocated to the nucleus Mus musculus 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.11 Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.11 ATP + CRE-binding protein Mus musculus i.e. CREB, a transcription factor, activition by type I PKA ADP + CRE-binding phosphoprotein
-
 ?
2.7.11.11 ATP + CREB-binding protein Mus musculus i.e. CBP, activition by type II PKA ADP + CREB-binding phosphoprotein
-
 ?
2.7.11.11 additional information Mus musculus PKA type I regulates ethanol-induced cAMP response element-mediated gene expression via activation of CREB-binding protein and inhibition of MAPK, regulation overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.11 Mus musculus
-
 2 types of PKA
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.11 NG-108-15 cell neuroblastoma x glioma hybrid cell Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.11 ATP + CRE-binding protein i.e. CREB, a transcription factor, activition by type I PKA Mus musculus ADP + CRE-binding phosphoprotein
-
 ?
2.7.11.11 ATP + CREB-binding protein i.e. CBP, activition by type II PKA Mus musculus ADP + CREB-binding phosphoprotein
-
 ?
2.7.11.11 additional information PKA type I regulates ethanol-induced cAMP response element-mediated gene expression via activation of CREB-binding protein and inhibition of MAPK, regulation overview Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.11 cAMP-dependent protein kinase type I
-
 Mus musculus
2.7.11.11 type I PKA
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.11 30
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.11 7
-
 assay at Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.11 ATP
-
 Mus musculus