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Literature summary extracted from

  • Zheng, Z.; Butler, K.D.; Tweten, R.K.; Mensa-Wilmot, K.
    Endosomes, glycosomes, and glycosylphosphatidylinositol catabolism in Leishmania major (2004), J. Biol. Chem., 279, 42106-42113.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.6.1.14 expression in Leishmania major Trypanosoma brucei

Protein Variants

EC Number Protein Variants Comment Organism
4.6.1.14 C184A exhibits activity in the range detected for the unmutated protein, deficiency of cell-associated gp63, localization in endo-lysosome Trypanosoma brucei
4.6.1.14 C269C/C270S/C273S exhibits activity in the range detected for the unmutated protein, localization in glycosome Trypanosoma brucei
4.6.1.14 C269S/C270S exhibits activity in the range detected for the unmutated protein, localization in glycosome Trypanosoma brucei
4.6.1.14 C269S/C273S exhibits activity in the range detected for the unmutated protein, localization in glycosome Trypanosoma brucei
4.6.1.14 C270S/C273S exhibits activity in the range detected for the unmutated protein, localization in glycosome Trypanosoma brucei
4.6.1.14 C347A exhibits activity in the range detected for the unmutated protein, deficiency of cell-associated gp63, localization in endo-lysosome Trypanosoma brucei
4.6.1.14 C80A exhibits activity in the range detected for the unmutated protein, localization in glycosome Trypanosoma brucei
4.6.1.14 Q81L inactive Trypanosoma brucei

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.6.1.14 glycosome in case of mutations on the endosome targeting motif, glycosomal GPI-PLC from Trypanosoma brucei fails to produce the glycosylphosphatidylinositol deficiency in Leishmania major Trypanosoma brucei 20015
-
4.6.1.14 additional information endo-lysosomal system, wild-type, endosomal GPI-PLC from Trypanosoma brucei causes a deficiency of protein glycosylphosphatidylinositols in Leishmania major Trypanosoma brucei
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.14 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol Trypanosoma brucei
-
 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.14 Trypanosoma brucei
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.6.1.14 652
-
-
 Trypanosoma brucei

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.14 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
-
 Trypanosoma brucei 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.6.1.14 glycosylphosphatidylinositol-specific phospholipase C
-
 Trypanosoma brucei
4.6.1.14 GPI-PLC
-
 Trypanosoma brucei