Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Ranganathan, S.; Liu, C.X.; Migliorini, M.M.; Von Arnim, C.A.; Peltan, I.D.; Mikhailenko, I.; Hyman, B.T.; Strickland, D.K.
    Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase Calpha regulates endocytosis and association with adaptor molecules (2004), J. Biol. Chem., 279, 40536-40544.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.13 K-252a strong inhibition Homo sapiens
2.7.11.13 additional information no inhibition by genistein and H-89 Homo sapiens
2.7.11.13 Ro-32-0432 strong inhibition Rattus norvegicus
2.7.11.13 staurosporine strong inhibition Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.13 ATP + [low density lipoprotein receptor-related protein] Homo sapiens involved in regulation of endocytosis and association with adaptor molecules, e.g. Shc, Dab1, or CED-6/GULP ADP + phosphorylated [low density lipoprotein receptor-related protein]
-
 ?
2.7.11.13 ATP + [low density lipoprotein receptor-related protein] Rattus norvegicus involved in regulation of endocytosis and association with adaptor molecules, e.g. Shc, Dab1, or CED-6/GULP ADP + phosphorylated [low density lipoprotein receptor-related protein]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.13 Homo sapiens
-
-
-
2.7.11.13 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.13 commercial preparation recombinant PKCalpha Homo sapiens
-
2.7.11.13 fibroblast
-
 Homo sapiens
-
2.7.11.13 lung
-
 Rattus norvegicus
-
2.7.11.13 smooth muscle cell pulmonary cell line Rattus norvegicus
-
2.7.11.13 WI-38 cell fibroblast cell line Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.13 ATP + [low density lipoprotein receptor-related protein] involved in regulation of endocytosis and association with adaptor molecules, e.g. Shc, Dab1, or CED-6/GULP Homo sapiens ADP + phosphorylated [low density lipoprotein receptor-related protein]
-
 ?
2.7.11.13 ATP + [low density lipoprotein receptor-related protein] involved in regulation of endocytosis and association with adaptor molecules, e.g. Shc, Dab1, or CED-6/GULP Rattus norvegicus ADP + phosphorylated [low density lipoprotein receptor-related protein]
-
 ?
2.7.11.13 ATP + [low density lipoprotein receptor-related protein] i.e. LPR, phosphorylation of cytoplasmic domain residues T63, T16, S3, S73, S76, and S79 Homo sapiens ADP + phosphorylated [low density lipoprotein receptor-related protein]
-
 ?
2.7.11.13 ATP + [low density lipoprotein receptor-related protein] i.e. LPR, phosphorylation of cytoplasmic domain serine and threonine residues Rattus norvegicus ADP + phosphorylated [low density lipoprotein receptor-related protein]
-
 ?
2.7.11.13 additional information activity with wild-type and mutant substrate low density lipoprotein receptor-related protein, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.13 PKCalpha
-
 Homo sapiens
2.7.11.13 PKCalpha
-
 Rattus norvegicus
2.7.11.13 protein kinase Calpha
-
 Homo sapiens
2.7.11.13 protein kinase Calpha
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.13 37
-
 assay at Homo sapiens
2.7.11.13 37
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.13 ATP
-
 Homo sapiens
2.7.11.13 ATP
-
 Rattus norvegicus