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Literature summary extracted from

  • Gardner, L.A.; Delos Santos, N.M.; Matta, S.G.; Whitt, M.A.; Bahouth, S.W.
    Role of the cyclic AMP-dependent protein kinase in homologous resensitization of the beta1-adrenergic receptor (2004), J. Biol. Chem., 279, 21135-21143.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.11 cAMP dependent on Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.11 additional information construction and expression of enzyme with inactive cAMP binding sites at the regulatory subunits resulting in impaired beta1-adrenergic receptor recycling in recombinant HEK-293 cells, overview Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.11 H-89 specific inhibitor Homo sapiens
2.7.11.11 myristoylated PKI specific inhibitor Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.11 cytoplasm
-
 Homo sapiens 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.11 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.11 ATP + beta1-adrenergic receptor Homo sapiens recombinant beta1-adrenergic receptor expressed in HEK-293 cell membranes, phosphorylation at Ser312 is essential for activation of endocytic recycling of the agonist-internalized beta1-adrenergic receptor, beta1-AR mutant S312A is not recycled, overview ADP + phosphorylated beta1-adrenergic receptor
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.11 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.11 HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.11 ATP + beta1-adrenergic receptor recombinant beta1-adrenergic receptor expressed in HEK-293 cell membranes, phosphorylation at Ser312 is essential for activation of endocytic recycling of the agonist-internalized beta1-adrenergic receptor, beta1-AR mutant S312A is not recycled, overview Homo sapiens ADP + phosphorylated beta1-adrenergic receptor
-
 ?
2.7.11.11 ATP + beta1-adrenergic receptor phosphorylation at Ser312 in the third intracellular loop of the receptor protein by the PKA catalytic subunit Homo sapiens ADP + phosphorylated beta1-adrenergic receptor
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.11 cyclic AMP-dependent protein kinase
-
 Homo sapiens
2.7.11.11 PKA
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.11 ATP
-
 Homo sapiens