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Literature summary extracted from

  • Piontek, J.; Brandt, R.
    Differential and regulated binding of cAMP-dependent protein kinase and protein kinase C isoenzymes to gravin in human model neurons: evidence that gravin provides a dynamic platform for the localization of kinases during neuronal development (2003), J. Biol. Chem., 278, 38970-38979.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.11 cAMP dependent on Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.11 additional information the enzyme binds to and colocalizes with the kinase-anchoring protein gravin in the neuronal cortex membrane which is enriched in the inner peripheral cortex in close proximity to the plasma membrane Homo sapiens
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.11 additional information Homo sapiens the enzyme interacts with the neuron cortex membrane protein gravin via Ca2+-independent binding to the regulatory RII enzyme subunit, gravin provides a platform to localize kinases, besides PKA also PKCalpha and PKCbetaII, in an isozyme-specific and activation-dependent manner at specific sites in neurons, gravin is strongly upregulated in cells during differentiation, overview ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.11 Homo sapiens
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.11 NT2-N cell precursor-like neuronal cells and differentiated NT2 cells, model neurons Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.11 additional information the enzyme interacts with the neuron cortex membrane protein gravin via Ca2+-independent binding to the regulatory RII enzyme subunit, gravin provides a platform to localize kinases, besides PKA also PKCalpha and PKCbetaII, in an isozyme-specific and activation-dependent manner at specific sites in neurons, gravin is strongly upregulated in cells during differentiation, overview Homo sapiens ?
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 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.11 oligomer
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 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.11.11 PKA
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 Homo sapiens