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Literature summary extracted from

  • Zhou, R.; Cao, X.; Watson, C.; Miao, Y.; Guo, Z.; Forte, J.G.; Yao, X.
    Characterization of protein kinase A-mediated phosphorylation of ezrin in gastric parietal cell activation (2003), J. Biol. Chem., 278, 35651-35659.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.11 cAMP dependent on Oryctolagus cuniculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.11 additional information substrate ezrin is localized at the cytoskeleton of the apical plasma membrane Oryctolagus cuniculus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.11 Mg2+
-
 Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.11 ATP + ezrin Oryctolagus cuniculus recombinant GST-tagged wild-type ezrin transiently expressed in primary gastric parietal cells from stomach, recombinant mutant S66A and S66D ezrin proteins are no substrates, phosphorylation of ezrin leads to activation of parietal cells required for dilation of apical vacuolar membrane and histamine-stimulated acid secretion in gastric mucosa, overview ADP + phosphoezrin
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.11 Oryctolagus cuniculus
-
 New Zealand white rabbits
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.11 gastric gland
-
 Oryctolagus cuniculus
-
2.7.11.11 mucosa gastric Oryctolagus cuniculus
-
2.7.11.11 stomach
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.11 ATP + ezrin recombinant GST-tagged wild-type ezrin transiently expressed in primary gastric parietal cells from stomach, recombinant mutant S66A and S66D ezrin proteins are no substrates, phosphorylation of ezrin leads to activation of parietal cells required for dilation of apical vacuolar membrane and histamine-stimulated acid secretion in gastric mucosa, overview Oryctolagus cuniculus ADP + phosphoezrin
-
 ?
2.7.11.11 ATP + ezrin phosphorylation at Ser66, catalytic subunit of PKA Oryctolagus cuniculus ADP + phosphoezrin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.11 PKA
-
 Oryctolagus cuniculus
2.7.11.11 protein kinase A
-
 Oryctolagus cuniculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.11 22
-
 assay at room temperature Oryctolagus cuniculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.11 7.5
-
 assay at Oryctolagus cuniculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.11 ATP
-
 Oryctolagus cuniculus