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Literature summary extracted from

  • Agarwal-Mawal, A.; Qureshi, H.Y.; Cafferty, P.W.; Yuan, Z.; Han, D.; Lin, R.; Paudel, H.K.
    14-3-3 connects glycogen synthase kinase-3 beta to tau within a brain microtubule-associated tau phosphorylation complex (2003), J. Biol. Chem., 278, 12722-12728.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.1 protein 14-3-3 a dimeric scaffold protein, protein is absolutely required for connection by simultaneous binding of glycogen synthase kinase-3 beta to tau within a brain microtubule-associated tau phosphorylation complex Bos taurus
2.7.11.26 protein 14-3-3 a dimeric scaffold protein, protein is absolutely required for connection by simultaneous binding of glycogen synthase kinase-3 beta to tau within a brain microtubule-associated tau phosphorylation complex Bos taurus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.1 co-expression of glycogen synthase kinase-3 beta, tau, and 14-3-3 in COS-7 cells and in HEK-293 cells Bos taurus
2.7.11.26 co-expression of glycogen synthase kinase-3 beta, tau, and 14-3-3 in COS-7 cells and in HEK-293 cells Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.1 cytoskeleton
-
 Bos taurus 5856
-
2.7.11.26 cytoskeleton
-
 Bos taurus 5856
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.1 Mg2+
-
 Bos taurus
2.7.11.26 Mg2+
-
 Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.1 ATP + [tau-protein] Bos taurus substrate of GSK3beta in brain ADP + O-phospho-[tau-protein]
-
 ?
2.7.11.1 additional information Bos taurus glycogen synthase kinase-3beta also performs the tau-protein kinase reaction, EC 2.7.11.26, phosphorylating tau protein at serine and threonine residues ?
-
 ?
2.7.11.26 ATP + [tau-protein] Bos taurus 14-3-3 connects glycogen synthase kinase-3 beta to tau within a brain microtubule-associated tau phosphorylation complex ADP + O-phospho-[tau-protein]
-
 ?
2.7.11.26 additional information Bos taurus glycogen synthase kinase-3beta also performs serine/threonine protein kinase reaction, EC 2.7.11.1, with other substrates than tau, e.g. it phosphorylates the glycogen synthase ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.1 Bos taurus
-
-
-
2.7.11.26 Bos taurus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.11.1 ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate glycogen synthase kinase-3beta also performs the tau-protein kinase reaction, EC 2.7.11.26 Bos taurus
a
2.7.11.26 ATP + [tau-protein] = ADP + O-phospho-[tau-protein] glycogen synthase kinase-3beta also performs serine/threonine protein kinase reaction, EC 2.7.11.1, with other substrates than tau, e.g. it phosphorylates the glycogen synthase Bos taurus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.1 brain
-
 Bos taurus
-
2.7.11.26 brain
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.1 ATP + [tau-protein]
-
 Bos taurus ADP + O-phospho-[tau-protein]
-
 ?
2.7.11.1 ATP + [tau-protein] substrate of GSK3beta in brain Bos taurus ADP + O-phospho-[tau-protein]
-
 ?
2.7.11.1 additional information glycogen synthase kinase-3beta also performs the tau-protein kinase reaction, EC 2.7.11.26, phosphorylating tau protein at serine and threonine residues Bos taurus ?
-
 ?
2.7.11.26 ATP + [tau-protein]
-
 Bos taurus ADP + O-phospho-[tau-protein]
-
 ?
2.7.11.26 ATP + [tau-protein] 14-3-3 connects glycogen synthase kinase-3 beta to tau within a brain microtubule-associated tau phosphorylation complex Bos taurus ADP + O-phospho-[tau-protein]
-
 ?
2.7.11.26 additional information glycogen synthase kinase-3beta also performs serine/threonine protein kinase reaction, EC 2.7.11.1, with other substrates than tau, e.g. it phosphorylates the glycogen synthase Bos taurus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.26 More 14-3-3 connects glycogen synthase kinase-3 beta to tau within a brain microtubule-associated tau phosphorylation complex Bos taurus

Synonyms

EC Number Synonyms Comment Organism
2.7.11.1 glycogen synthase kinase-3beta
-
 Bos taurus
2.7.11.1 More see also EC 2.7.11.26 Bos taurus
2.7.11.26 glycogen synthase kinase-3beta
-
 Bos taurus
2.7.11.26 More see also EC 2.7.11.1 Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.1 ATP
-
 Bos taurus
2.7.11.26 ATP
-
 Bos taurus