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Literature summary extracted from

  • Verbsky, J.W.; Wilson, M.P.; Kisseleva, M.V.; Majerus, P.W.; Wente, S.R.
    The synthesis of inositol hexakisphosphate. Characterization of human inositol 1,3,4,5,6-pentakisphosphate 2-kinase (2002), J. Biol. Chem., 277, 31857-31862.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.158 expression in Sf21 cells. Expression of the human enzyme in yeast ipk null strain restores synthesis of 1D-myo-inositol hexakisphosphate and rescues the gle1-2 ipk1-4 lethal phenotype Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.158 0.0004
-
 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 Homo sapiens
2.7.1.158 0.021
-
 ATP
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.158 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.158 recombinant Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.158 brain
-
 Homo sapiens
-
2.7.1.158 heart
-
 Homo sapiens
-
2.7.1.158 placenta
-
 Homo sapiens
-
2.7.1.158 testis
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.158 0.031
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.158 ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 Homo sapiens ADP + 1D-myo-inositol hexakisphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.158 inositol 1,3,4,5,6-pentakisphosphate 2-kinase
-
 Homo sapiens
2.7.1.158 Ins5 2-kinase
-
 Homo sapiens