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Literature summary extracted from

  • Violin, J.D.; Newton, A.C.
    Pathway illuminated: visualizing protein kinase C signaling (2003), IUBMB Life, 55, 653-660.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.13 diacylglycerol required, second messenger involved in PKC regulation Mus musculus
2.7.11.13 diacylglycerol required, second messenger involved in PKC regulation Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.13 expression of GFP-tagged PKC Mus musculus
2.7.11.13 expression of GFP-tagged PKC Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.13 additional information construction of PKC isozyme-deletion mutant mice leading to important metabolic deficiencies in the mutant mice Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.13 membrane bound to via second messengers and phorbol esters, the ligand-binding domains are required for membrane targeting Mus musculus 16020
-
2.7.11.13 membrane bound to via second messengers and phorbol esters, the ligand-binding domains are required for membrane targeting Homo sapiens 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.13 Ca2+ required, second messenger involved in PKC regulation, some isozymes are Ca2+-independent Mus musculus
2.7.11.13 Ca2+ required, second messenger involved in PKC regulation, some isozymes are Ca2+-independent Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.13 additional information Homo sapiens the enzyme is important in signal transduction from extracellular signals to intracellular responses involving the second messengers Ca2+ and diacylglycerol, processing mechanism and regulation overview ?
-
 ?
2.7.11.13 additional information Mus musculus the enzyme is important in signal transduction from extracellular signals to intracellular responses involving the second messengers Ca2+ and diacylglycerol, processing mechanism and regulation overview, PKC is important in diverse biological functions, e.g. in cell proliferation, cell differentiation, immune response, cancer, and memory ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.13 Homo sapiens
-
 several isozymes
-
2.7.11.13 Mus musculus
-
 several isozymes
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.13 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.13 additional information the enzyme is important in signal transduction from extracellular signals to intracellular responses involving the second messengers Ca2+ and diacylglycerol, processing mechanism and regulation overview Homo sapiens ?
-
 ?
2.7.11.13 additional information the enzyme is important in signal transduction from extracellular signals to intracellular responses involving the second messengers Ca2+ and diacylglycerol, processing mechanism and regulation overview, PKC is important in diverse biological functions, e.g. in cell proliferation, cell differentiation, immune response, cancer, and memory Mus musculus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.13 More PKC domain composition Mus musculus
2.7.11.13 More PKC domain composition Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.11.13 PKC
-
 Mus musculus
2.7.11.13 PKC
-
 Homo sapiens