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Literature summary extracted from

  • Mottet, D.; Ruys, S.P.; Demazy, C.; Raes, M.; Michiels, C.
    Role for casein kinase 2 in the regulation of HIF-1 activity (2005), Int. J. Cancer, 117, 764-774.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.1 2-Aminopurine
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.1 cytoplasm CKalpha in normoxia Homo sapiens 5737
-
2.7.11.1 membrane CK2beta in hypoxia Homo sapiens 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.1 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.1 ATP + hypoxia-inducible factor-1 Homo sapiens i.e. HIF-1, casein kinase 2 inhibits the activation of HIF-1 activity by phosphorylation and thereby stabilization of the protein, CK2 is involved in and influenced by hypoxia, overview ADP + phosphorylated hypoxia-inducible factor-1
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.1 Hep-G2 cell
-
 Homo sapiens
-
2.7.11.1 hepatoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.1 ATP + hypoxia-inducible factor-1 i.e. HIF-1, casein kinase 2 inhibits the activation of HIF-1 activity by phosphorylation and thereby stabilization of the protein, CK2 is involved in and influenced by hypoxia, overview Homo sapiens ADP + phosphorylated hypoxia-inducible factor-1
-
 ?
2.7.11.1 ATP + hypoxia-inducible factor-1 i.e. HIF-1 Homo sapiens ADP + phosphorylated hypoxia-inducible factor-1
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.1 casein kinase 2
-
 Homo sapiens
2.7.11.1 CK2
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.1 7.5
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.1 ATP
-
 Homo sapiens