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Literature summary extracted from

  • Jana, S.; Deb, J.K.
    Kinetic mechanism of streptomycin adenylyltransferase from a recombinant Escherichia coli (2005), Biotechnol. Lett., 27, 519-524.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.47 neomycin non-competitive versus streptomycin and uncompetitive versus ATP Escherichia coli
2.7.7.47 tobramycin non-competitive versus streptomycin and uncompetitive versus ATP Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.47 ATP + streptomycin Escherichia coli important mechanism of streptomycin modification is through ATP-dependent O -adenylation diphosphate + 3''-adenylylstreptomycin
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Organism

EC Number Organism UniProt Comment Textmining
2.7.7.47 Escherichia coli
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.47 ATP + streptomycin important mechanism of streptomycin modification is through ATP-dependent O -adenylation Escherichia coli diphosphate + 3''-adenylylstreptomycin
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2.7.7.47 ATP + streptomycin sequential mechanism, ordered substrate binding where ATP binds first and then streptomycin and diphosphate is released prior to formation of AMP-streptomycin Escherichia coli diphosphate + 3''-adenylylstreptomycin
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