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Literature summary extracted from

  • Norris, A.J.; Whitelegge, J.P.; Strouse, M.J.; Faull, K.F.; Toyokuni, T.
    Inhibition kinetics of carba- and C-fucosyl analogues of GDP-fucose against fucosyltransferase V: implication for the reaction mechanism (2004), Bioorg. Med. Chem. Lett., 14, 571-573.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.65 C-fucosyl analogon of GDP-fucose
-
 Homo sapiens
2.4.1.65 carba-fucosyl analogon of GDP-fucose
-
 Homo sapiens
2.4.1.65 unsaturated carba-fucosyl analogon of GDP-fucose
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.65 0.0504
-
 GDP-fucose
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.65 Mn2+ Fuc-T V is Mn2+ dependent Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.65 GDP-fucose + Gal-beta-1,4GlcNAc-beta-1-R Homo sapiens
-
 GDP + Gal-beta-1,4(fuc-alpha-1,3)GlcNAc-beta-1-R
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.65 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.65 GDP-fucose + Gal-beta-1,4GlcNAc-beta-1-R
-
 Homo sapiens GDP + Gal-beta-1,4(fuc-alpha-1,3)GlcNAc-beta-1-R
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.65 Fuc-T
-
 Homo sapiens
2.4.1.65 fucosyltransferase V
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.1.65 0.0256
-
 unsaturated carba-fucosyl analogon of GDP-fucose
-
 Homo sapiens
2.4.1.65 0.0671
-
 carba-fucosyl analogon of GDP-fucose
-
 Homo sapiens
2.4.1.65 0.889
-
 C-fucosyl analogon of GDP-fucose
-
 Homo sapiens