Literature summary extracted from

Nagahara, N.; Sawada, N.; Nakagawa, T.
Affinity labeling of a catalytic site, cysteine(247), in rat mercaptopyruvate sulfurtransferase by chloropyruvate as an analog of a substrate (2004), Biochimie, 86, 723-729.

Protein Variants

EC Number	Protein Variants	Comment	Organism
2.8.1.2	R187G	Ki-value for 3-chloropyruvate similar to wild-type	Rattus norvegicus
2.8.1.2	R196G	5fold increase in Ki-value for 3-chloropyruvate	Rattus norvegicus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.8.1.2	3-Chloropyruvate	one-on-one manner of inactivation, pseudo first-order kinetics	Rattus norvegicus

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.8.1.2	Rattus norvegicus	-	recombinant enzyme	-

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
2.8.1.2	3.74	-	3-Chloropyruvate	pH 9.7, 25°C, mutant R196G	Rattus norvegicus
2.8.1.2	4	-	3-Chloropyruvate	pH 9.7, 25°C, wild-type	Rattus norvegicus
2.8.1.2	20	-	3-Chloropyruvate	pH 9.7, 25°C, mutant R187G	Rattus norvegicus

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Release 2023.1 (January 2023)