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Literature summary extracted from

  • Taneva, S.G.; Patty, P.J.; Frisken, B.J.; Cornell, R.B.
    CTP:phosphocholine cytidylyltransferase binds anionic phospholipid vesicles in a cross-bridging mode (2005), Biochemistry, 44, 9382-9393.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.7.15 Lipids regulation of activity by reversible association with membrane lipids, activation of enzyme when bound to lipid vesicles, vesicles containing 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-L-serine or egg phosphatidylglycerol are more effective than vesicles containing 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 1,2-dioleoyl-sn-glycerol, or egg phosphatidylcholine Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.15 expressed in High 5 cells Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.15 membrane enzyme is activated when bound to vesicles Rattus norvegicus 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.15 CTP + choline phosphate Rattus norvegicus rate limiting enzyme for the synthesis of phosphatidylcholine diphosphate + CDP-choline
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.15 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.7.15 phosphoprotein C-terminal region is highly phosphorylated, phosphorylation decreases membrane affinity and is therefore involved in regulation of enzyme activity Rattus norvegicus

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.7.15 recombinant protein Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.15 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.15 CTP + choline phosphate
-
 Rattus norvegicus diphosphate + CDP-choline
-
 ?
2.7.7.15 CTP + choline phosphate rate limiting enzyme for the synthesis of phosphatidylcholine Rattus norvegicus diphosphate + CDP-choline
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.7.15 dimer
-
 Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
2.7.7.15 CCTalpha
-
 Rattus norvegicus