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Literature summary extracted from

  • Wang, H.; Kruszewski, A.; Brautigan, D.L.
    Cellular chromium enhances activation of insulin receptor kinase (2005), Biochemistry, 44, 8167-8175.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.10.1 Insulin activates enzyme tyrosine autophosphorylation Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.10.1 expression of insulin receptor kinase in CHO cells as GST-fusion protein Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.10.1 plasma membrane
-
 Homo sapiens 5886
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.10.1 Cr3+ activates insulin receptor tyrosine phosphorylation in vivo Homo sapiens
2.7.10.1 Mg2+
-
 Homo sapiens
2.7.10.1 Mn2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.1 additional information Homo sapiens the insulin receptor tyrosine kinase performs insulin-induced autophosphorylation, regulatory dephosphorylation by protein tyrosine phosphatase PTP1B ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.1 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.10.1 phosphoprotein tyrosine autophosphorylation of the insulin receptor kinase induced by insulin binding, also in vivo tyrosine autophosphorylation in recombinant CHO cells after addition of insulin, dephosphorylation by protein tyrosine phosphatase PTP1B Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.1 ATP + KKHTDDGYMPMSPGVA commercial peptide substrate Homo sapiens ADP + KKHTDDGY-phosphate-MPMSPGVA
-
 ?
2.7.10.1 ATP + KKSRGDYMTMQIG commercial peptide substrate Homo sapiens ADP + KKSRGDY-phosphate-MTMQIG
-
 ?
2.7.10.1 additional information the insulin receptor tyrosine kinase performs insulin-induced autophosphorylation, regulatory dephosphorylation by protein tyrosine phosphatase PTP1B Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.10.1 insulin receptor kinase
-
 Homo sapiens
2.7.10.1 IR kinase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.10.1 30
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.10.1 7.5
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.10.1 ATP
-
 Homo sapiens