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Literature summary extracted from

  • Cooper, A.J.; Pinto, J.T.
    Aminotransferase, L-amino acid oxidase and beta-lyase reactions involving L-cysteine S-conjugates found in allium extracts. Relevance to biological activity? (2005), Biochem. Pharmacol., 69, 209-220.
    View publication on PubMed

Application

EC Number Application Comment Organism
4.4.1.13 medicine several cysteine S-conjugates that occur in extracts of garlic and other plants of the Allium family possess anti-oxidant properties and are promising anti-cancer agents Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.4.1.13 cytosol
-
 Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.4.1.13 RS-CH2-CH(NH3+)COO- + H2O Rattus norvegicus
-
 RSH + NH3 + pyruvate
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.2 Crotalus adamanteus
-
-
-
4.4.1.13 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.4.1.13
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.4.1.13 kidney
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.2 (1,1,2,2-tetrafluoroethyl)-L-cysteine + H2O + O2 80% of the activity with L-methionine Crotalus adamanteus 2-oxo-3-[(1,1,2,2-tetrafluoroethyl)sulfanyl]propanoic acid + NH3 + H2O2
-
 ?
1.4.3.2 L-cysteine + H2O + O2 40% of the activity with L-methionine Crotalus adamanteus 2-oxo-3-mercaptopropanoic acid + NH3 + H2O2
-
 ?
1.4.3.2 L-cystine + H2O + O2 35% of the activity with L-methionine Crotalus adamanteus ? + NH3 + H2O2
-
 ?
1.4.3.2 L-glutamine + H2O + O2 10% of the activity with L-methionine Crotalus adamanteus 2-oxoglutaramate + NH3 + H2O2
-
 ?
1.4.3.2 L-methionine + H2O + O2
-
 Crotalus adamanteus 4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
 ?
1.4.3.2 S-allyl-L-cysteine + H2O + O2 94% of the activity with L-methionine Crotalus adamanteus 2-oxo-3-(prop-2-en-1-ylsulfanyl)propanoic acid + NH3 + H2O2
-
 ?
1.4.3.2 S-allylmercapto-L-cysteine + H2O + O2 26% of the activity with L-methionine Crotalus adamanteus 2-oxo-3-[(2-thioxoethyl)sulfanyl]propanoic acid + NH3 + H2O2
-
 ?
1.4.3.2 S-benzothiazolyl-L-cysteine + H2O + O2 161% of the activity with L-methionine Crotalus adamanteus 3-(1,3-benzothiazol-3(2H)-ylsulfanyl)-2-oxopropanoic acid + NH3 + H2O2
-
 ?
1.4.3.2 S-methylmercapto-L-cysteine + H2O + O2 66% of the activity with L-methionine Crotalus adamanteus ? + NH3 + H2O2
-
 ?
1.4.3.2 S-penta-1,3-dienylmercapto-L-cysteine + H2O + O2 7% of the activity with L-methionine Crotalus adamanteus ? + NH3 + H2O2
-
 ?
1.4.3.2 S-propylmercapto-L-cysteine + H2O + O2 16% of the activity with L-methionine Crotalus adamanteus 2-oxo-3-[(3-thioxopropyl)sulfanyl]propanoic acid + NH3 + H2O2
-
 ?
4.4.1.13 additional information no reaction with S-benzothiazolyl-L-cysteine Rattus norvegicus ?
-
 ?
4.4.1.13 RS-CH2-CH(NH3+)COO- + H2O
-
 Rattus norvegicus RSH + NH3 + pyruvate
-
 ir
4.4.1.13 S-(1,1,2,2-tetrafluoroethyl)-L-cysteine + H2O
-
 Rattus norvegicus NH3 + pyruvate + 1,1,2,2-tetrafluoroethanethiol
-
 ir
4.4.1.13 S-allyl-L-cysteine + H2O
-
 Rattus norvegicus NH3 + pyruvate + prop-2-ene-1-thiol
-
 ir
4.4.1.13 S-allylmercapto-L-cysteine + H2O
-
 Rattus norvegicus NH3 + pyruvate + allyl hydrodisulfide
-
 ir
4.4.1.13 S-methylmercapto-L-cysteine + H2O
-
 Rattus norvegicus NH3 + pyruvate + methanethiol
-
 ir
4.4.1.13 S-penta-1,3-dienylmercapto-L-cysteine + H2O
-
 Rattus norvegicus NH3 + pyruvate + penta-1,3-dien-1-yl hydrodisulfide
-
 ir
4.4.1.13 S-propylmercapto-L-cysteine + H2O
-
 Rattus norvegicus NH3 + pyruvate + propyl hydrodisulfide
-
 ir

Synonyms

EC Number Synonyms Comment Organism
4.4.1.13 glutamine transaminase K
-
 Rattus norvegicus
4.4.1.13 GTK
-
 Rattus norvegicus