Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Lee, L.T.; Huang, Y.T.; Hwang, J.J.; Lee, A.Y.; Ke, F.C.; Huang, C.J.; Kandaswami, C.; Lee, P.P.; Lee, M.T.
    Transinactivation of the epidermal growth factor receptor tyrosine kinase and focal adhesion kinase phosphorylation by dietary flavonoids: effect on invasive potential of human carcinoma cells (2004), Biochem. Pharmacol., 67, 2103-2114.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.10.1 Epidermal growth factor activates the tyrosine kinase activity of the epidermal growth factor receptor promoting cell growth Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.10.1 luteolin dietary flavonoid, transinactivation of epidermal growth factor receptor tyrosine kinase and blocking of downstream signaling pathways activation, and cell migration in MiaPaCa-2 cells Homo sapiens
2.7.10.1 quercetin dietary flavonoid, transinactivation of epidermal growth factor receptor tyrosine kinase and blocking of downstream signaling pathways activation, and cell migration in MiaPaCa-2 cells Homo sapiens
2.7.10.1 wogonin slight inhibitory effect on epidermal growth factor receptor tyrosine kinase Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.10.1 membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.1 additional information Homo sapiens enzyme transactivation stimulates cell migration and the subsequent activation of downstream signaling pathways ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.1 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.10.1 phosphoprotein EGFR tyrosine kinase is activated by tyrosine phosphorylation, and the activated enzyme stimulates phosphorylation of diverse cellular proteins, overview Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.10.1 A-431 cell skin tumor cell line Homo sapiens
-
2.7.10.1 MiaPaCa-2 cell pancreas tumor cell line Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.1 additional information enzyme transactivation stimulates cell migration and the subsequent activation of downstream signaling pathways Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.10.1 EGFR tyrosine kinase
-
 Homo sapiens
2.7.10.1 epidermal growth factor receptor tyrosine kinase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.10.1 22
-
 assay at room temperature Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.10.1 7.4
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.10.1 ATP
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.10.1 additional information
-
 additional information
-
 Homo sapiens