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Literature summary extracted from

  • Xu, Z.H.; Thomae, B.A.; Eckloff, B.W.; Wieben, E.D.; Weinshilboum, R.M.
    Pharmacogenetics of human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPSS1): gene resequencing, sequence variation, and functional genomics (2003), Biochem. Pharmacol., 65, 1787-1796.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.25 expressed in COS-1 and HEK293 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.25 E531Q identified as naturally occurring mutation, E531Q found in a single sample of an African-American’s subject, almost no effect of mutations when expressed in COS-1 or HEK293 cells Homo sapiens
2.7.1.25 R333C identified as naturally occurring mutation, R333C found exclusively in Caucasian-American’s DNA, almost no effect of mutations when expressed in COS-1 or HEK293 cells Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.25 ATP + adenosine 5'-phosphosulfate Homo sapiens involved in the synthesis of the important sulfate donor 3'-phosphoadenosine 5'-phosphosulfate from ATP and sulfate, inactivating mutations of PAPSS2 causes skeletal disorders ADP + 3'-phosphoadenosine 5'-phosphosulfate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.25 Homo sapiens O43252 PAPSS1; Caucasian-American and African-American subjects
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.25 brain
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.25 ATP + adenosine 5'-phosphosulfate
-
 Homo sapiens ADP + 3'-phosphoadenosine 5'-phosphosulfate
-
 ?
2.7.1.25 ATP + adenosine 5'-phosphosulfate involved in the synthesis of the important sulfate donor 3'-phosphoadenosine 5'-phosphosulfate from ATP and sulfate, inactivating mutations of PAPSS2 causes skeletal disorders Homo sapiens ADP + 3'-phosphoadenosine 5'-phosphosulfate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.25 PAPSS PAPS synthetase, two isoforms: PAPSS1 and PAPSS2 Homo sapiens