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Literature summary extracted from

  • Randi, A.S.; Sancovich, H.A.; Ferramola de Sancovich, A.M.; Loaiza, A.; Kolliker Frers, R.A.; Spinelli, F.; Kleiman de Pisarev, D.L.
    Effect of in vivo administered hexachlorobenzene on epidermal growth factor receptor levels, protein tyrosine kinase activity, and phosphotyrosine content in rat liver (2003), Biochem. Pharmacol., 65, 1495-1506.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.10.1 hexachlorobenzene increases after in vivo administration the total epidermal growth factor receptor content and decreases the plasma membrane epidermal growth factor receptor content compared to untreated rats, higher enzyme activity at low doses, reduced enzyme activity at higher doses of hexachlorobenzene Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.10.1 hexachlorobenzene increases after in vivo administration the total epidermal growth factor receptor content and decreases the plasma membrane epidermal growth factor receptor content compared to untreated rats, higher enzyme activity at low doses of 1 mg per kg body weight, reduced enzyme activity at higher doses of 100 mg hexachlorobenzene per kg body weight and above, chronic treatment induces a down-regulation of epidermal growth factor receptor and increases the EGFR-tyrosine kinase activity in the microsomal fraction Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.10.1 microsome
-
 Rattus norvegicus
-
-
2.7.10.1 plasma membrane
-
 Rattus norvegicus 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.1 ATP + a [protein]-L-tyrosine Rattus norvegicus
-
 ADP + a [protein]-L-tyrosine phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.1 Rattus norvegicus
-
 female Wistar rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.10.1 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.1 ATP + a [protein]-L-tyrosine
-
 Rattus norvegicus ADP + a [protein]-L-tyrosine phosphate
-
 ?
2.7.10.1 ATP + a [protein]-L-tyrosine substrates are membrane and cytosolic proteins Rattus norvegicus ADP + a [protein]-L-tyrosine phosphate
-
 ?
2.7.10.1 ATP + poly-(Glu-Tyr)
-
 Rattus norvegicus ADP + poly-(Glu-Tyr) phosphate Tyr-phosphate ?

Synonyms

EC Number Synonyms Comment Organism
2.7.10.1 EGFR-tyrosine kinase
-
 Rattus norvegicus
2.7.10.1 epidermal growth factor receptor
-
 Rattus norvegicus
2.7.10.1 Protein tyrosine kinase
-
 Rattus norvegicus
2.7.10.1 PTK
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.10.1 30
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.10.1 7
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.10.1 ATP
-
 Rattus norvegicus