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Literature summary extracted from

  • Xue, J.; Milburn, P.J.; Hanna, B.T.; Graham, M.E.; Rostas, J.A.; Robinson, P.J.
    Phosphorylation of septin 3 on Ser-91 by cGMP-dependent protein kinase-I in nerve terminals (2004), Biochem. J., 381, 753-760.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.12 8-pCPT-CGMP i.e. 8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphate Bos taurus
2.7.11.12 cGMP
-
 Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.11.12 0.0865
-
 septin 3 peptide 86-98 pH 7.4, 30°C, PKG-I Bos taurus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.12 Mg2+
-
 Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.12 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.12 lung
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.11.12 additional information
-
-
 Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.12 ATP + septin 3 substrate from rat nerves: recombinant His-tagged septin 3 expressed in Escherichia coli or purified from brain and prepared in synaptosomes, phosphorylation at Ser91 and Ser92, no activity with septin 3 mutants S91A and S92A Bos taurus ADP + phosphorylated septin 3
-
 ?
2.7.11.12 ATP + septin 3 peptide 86-98
-
 Bos taurus ADP + phosphorylated septin 3 peptide 86-98
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.12 cGMP-dependent protein kinase-I
-
 Bos taurus
2.7.11.12 PKG-I
-
 Bos taurus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.12 30
-
 assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.12 7.4
-
 assay at Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.12 ATP
-
 Bos taurus