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Literature summary extracted from
- Novel amidohydrolytic reactions in oxidative pyrimidine metabolism: analysis of the barbiturase reaction and discovery of a novel enzyme, ureidomalonase (2001), Biochem. Biophys. Res. Commun., 286, 222-226.
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 1.17.99.4 | enzyme in cell-free extract is unstable, activity totally diappears within 3 days | Rhodococcus erythropolis |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.17.99.4 | thymine + H2O + acceptor | Rhodococcus erythropolis | involved in oxidative pyrimidine metabolism | 5-methylbarbiturate + reduced acceptor | - |
? |  |
| 1.17.99.4 | thymine + H2O + acceptor | Rhodococcus erythropolis JCM 3132 | involved in oxidative pyrimidine metabolism | 5-methylbarbiturate + reduced acceptor | - |
? | |
| 1.17.99.4 | uracil + H2O + acceptor | Rhodococcus erythropolis | involved in oxidative pyrimidine metabolism | barbiturate + reduced acceptor | - |
? | |
| 1.17.99.4 | uracil + H2O + acceptor | Rhodococcus erythropolis JCM 3132 | involved in oxidative pyrimidine metabolism | barbiturate + reduced acceptor | - |
? | |
| 3.5.1.95 | ureidomalonic acid + H2O | Rhodococcus erythropolis | reaction in oxidative pyrimidine metabolism | malonate + urea | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.17.99.4 | Rhodococcus erythropolis | - |
JCM 3132 | - |
| 1.17.99.4 | Rhodococcus erythropolis JCM 3132 | - |
JCM 3132 | - |
| 3.5.1.95 | Rhodococcus erythropolis | - |
JCM3132 | - |
| 3.5.1.95 | Rhodococcus erythropolis JCM 3132 | - |
JCM3132 | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.17.99.4 | thymine + H2O + acceptor | - |
Rhodococcus erythropolis | 5-methylbarbiturate + reduced acceptor | - |
? | |
| 1.17.99.4 | thymine + H2O + acceptor | involved in oxidative pyrimidine metabolism | Rhodococcus erythropolis | 5-methylbarbiturate + reduced acceptor | - |
? | |
| 1.17.99.4 | thymine + H2O + acceptor | - |
Rhodococcus erythropolis JCM 3132 | 5-methylbarbiturate + reduced acceptor | - |
? | |
| 1.17.99.4 | thymine + H2O + acceptor | involved in oxidative pyrimidine metabolism | Rhodococcus erythropolis JCM 3132 | 5-methylbarbiturate + reduced acceptor | - |
? | |
| 1.17.99.4 | uracil + H2O + acceptor | - |
Rhodococcus erythropolis | barbiturate + reduced acceptor | - |
? | |
| 1.17.99.4 | uracil + H2O + acceptor | involved in oxidative pyrimidine metabolism | Rhodococcus erythropolis | barbiturate + reduced acceptor | - |
? | |
| 1.17.99.4 | uracil + H2O + acceptor | - |
Rhodococcus erythropolis JCM 3132 | barbiturate + reduced acceptor | - |
? | |
| 1.17.99.4 | uracil + H2O + acceptor | involved in oxidative pyrimidine metabolism | Rhodococcus erythropolis JCM 3132 | barbiturate + reduced acceptor | - |
? | |
| 3.5.1.95 | ureidomalonic acid + H2O | - |
Rhodococcus erythropolis | malonate + urea | - |
? | |
| 3.5.1.95 | ureidomalonic acid + H2O | reaction in oxidative pyrimidine metabolism | Rhodococcus erythropolis | malonate + urea | - |
? | |
| 3.5.1.95 | ureidomalonic acid + H2O | - |
Rhodococcus erythropolis JCM 3132 | malonate + urea | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.17.99.4 | EC 1.1.99.19 | formerly | Rhodococcus erythropolis |
| 1.17.99.4 | uracil dehydrogenase | - |
Rhodococcus erythropolis |
| 1.17.99.4 | uracil oxidase | - |
Rhodococcus erythropolis |
| 1.17.99.4 | uracil-thymidine oxidase | - |
Rhodococcus erythropolis |
| 3.5.1.95 | ureidomalonase | - |
Rhodococcus erythropolis |
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