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Literature summary extracted from

  • Wheeler, J.B.; Shaw, D.R.; Barnes, S.
    Purification and characterization of a rat liver bile acid coenzyme A ligase from rat liver microsomes (1997), Arch. Biochem. Biophys., 348, 15-24.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.2.1.7 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid 0.005 mM, 63% inhibition of the activity with chenodeoxycholate Rattus norvegicus
6.2.1.7 cholic acid 0.02 mM, 20% inhibition of the activity with chenodeoxycholate Rattus norvegicus
6.2.1.7 EDTA
-
 Rattus norvegicus
6.2.1.7 lithocholic acid 0.005 mM, 95% inhibition of the activity with chenodeoxycholate Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.2.1.7 0.018
-
 chenodeoxycholate
-
 Rattus norvegicus
6.2.1.7 0.548
-
 ATP
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.2.1.7 microsome
-
 Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.2.1.7 Mg2+ dependent on Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.2.1.7 65000
-
 x * 65000, SDS-PAGE Rattus norvegicus
6.2.1.7 243000
-
 gel filtration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.7 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.2.1.7
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.7 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.2.1.7 0.385
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.7 ATP + chenodeoxycholate + CoA
-
 Rattus norvegicus AMP + diphosphate + chenodeoxycholoyl-CoA
-
 ?

Subunits

EC Number Subunits Comment Organism
6.2.1.7 ? x * 65000, SDS-PAGE Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
6.2.1.7 bile acid coenzyme A ligase
-
 Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.2.1.7 8.5
-
-
 Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
6.2.1.7 8 9.6 pH 8.0: about 75% of maximal activity, pH 9.6: about 75% of maximal activity Rattus norvegicus