Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Barman, S.A.; Zhu, S.; Han, G.; White, R.E.
    cAMP activates BKCa channels in pulmonary arterial smooth muscle via cGMP-dependent protein kinase (2003), Am. J. Physiol., 284, L1004-1011.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.11 cAMP dependent on Rattus norvegicus
2.7.11.11 additional information forskolin activates via stimulation of cAMP production Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.11 KT5720 PKA inhibitor Rattus norvegicus
2.7.11.11 additional information no inhibition by KT5823 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.11 additional information Rattus norvegicus cAMP-dependent activation of BKCa channels in pulmonary arterial smooth muscle is not catalyzed by PKA but by cGMP-dependent protein kinase PKG, thus PKA is not involved in cAMP-induced signaling in pulmonary vasodilation ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.11 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.11 lung
-
 Rattus norvegicus
-
2.7.11.11 smooth muscle pulmonary arterial Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.11 additional information cAMP-dependent activation of BKCa channels in pulmonary arterial smooth muscle is not catalyzed by PKA but by cGMP-dependent protein kinase PKG, thus PKA is not involved in cAMP-induced signaling in pulmonary vasodilation Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.11 PKA
-
 Rattus norvegicus