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Literature summary extracted from

  • Baez-Saldana, A.; Zendejas-Ruiz, I.; Revilla-Monsalve, C.; Islas-Andrade, S.; Cardenas, A.; Rojas-Ochoa, A.; Vilches, A.; Fernandez-Mejia, C.
    Effects of biotin on pyruvate carboxylase, acetyl-CoA carboxylase, propionyl-CoA carboxylase, and markers for glucose and lipid homeostasis in type 2 diabetic patients and nondiabetic subjects (2004), Am. J. Clin. Nutr., 79, 238-243.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.4.1.1 biotin
-
 Homo sapiens
6.4.1.2 biotin induces the enzyme Homo sapiens
6.4.1.2 additional information the enzyme is not affected by D-glucose, insulin, triacylglycerol, cholesterol, or lactate Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.4.1.2 additional information the enzyme is not affected by D-glucose, insulin, triacylglycerol, cholesterol, or lactate Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.4.1.2 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.4.1.1 ATP + pyruvate + HCO3- Homo sapiens
-
 ADP + oxaloacetate + phosphate
-
 ?
6.4.1.2 additional information Homo sapiens the enzyme is critical in gluconeogenesis and lipid synthesis, nondiabetic and type 2 diabetic individuals show similar enzyme activity ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.4.1.1 Homo sapiens
-
-
-
6.4.1.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.4.1.1 lymphocyte
-
 Homo sapiens
-
6.4.1.2 lymphocyte circulating, of nondiabetic and type 2 diabetic individuals, female and male Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.4.1.1 43.8
-
 nondiabetic subjects Homo sapiens
6.4.1.1 47.8
-
 type 2 diabetic patients Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.4.1.1 ATP + pyruvate + HCO3-
-
 Homo sapiens ADP + oxaloacetate + phosphate
-
 ?
6.4.1.2 additional information the enzyme is critical in gluconeogenesis and lipid synthesis, nondiabetic and type 2 diabetic individuals show similar enzyme activity Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.4.1.1 PCC
-
 Homo sapiens
6.4.1.2 ACC
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.4.1.2 8
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
6.4.1.2 ATP
-
 Homo sapiens