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Literature summary extracted from

  • Amici, C.; Belardo, G.; Rozera, C.; Bernasconi, D.; Santoro, M.G.
    Inhibition of herpesvirus-induced HIV-1 replication by cyclopentenone prostaglandins: role of IkappaB kinase (IKK) (2004), Aids, 18, 1271-1280.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.10 additional information herpesvirus HSV-1 potently induces IkappaB kinase IKK causing persistent induction of NFkappaB resulting in transactivation of HIV-1-LTR-regulated genes and induction of HIV-1 replication in infected T-cells Homo sapiens

Application

EC Number Application Comment Organism
2.7.11.10 pharmacology enzyme is a target for development of inhibitors of HIV-1 replication, overview Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.10 15d-prostaglandin J2 strongly inhibits IKK Homo sapiens
2.7.11.10 cyclopentenone prostanoids inhibition of IKK and thus inhibition of NFkappaB-mediated HSV-1-induced HIV-1 replication Homo sapiens
2.7.11.10 prostaglandin 2alpha inhibits IKK Homo sapiens
2.7.11.10 prostaglandin A1 strongly inhibits IKK Homo sapiens
2.7.11.10 Prostaglandin A2 strongly inhibits IKK Homo sapiens
2.7.11.10 prostaglandin E1 inhibits IKK Homo sapiens
2.7.11.10 prostaglandin E2 inhibits IKK Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.10 additional information Homo sapiens IKK is responsible for activation of NFkappaB, herpesvirus HSV-1 potently induces IkappaB kinase IKK causing persistent induction of NFkappaB resulting in transactivation of HIV-1-LTR-regulated genes and induction of HIV-1 replication in infected T-cells ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.10 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.10 ACH-2 cell chronically infected with HIV-1 Homo sapiens
-
2.7.11.10 H9 cell chronically infected with HIV-1 Homo sapiens
-
2.7.11.10 JURKAT cell
-
 Homo sapiens
-
2.7.11.10 T-cell
-
 Homo sapiens
-
2.7.11.10 T-lymphoblastoid cell line
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.10 additional information IKK is responsible for activation of NFkappaB, herpesvirus HSV-1 potently induces IkappaB kinase IKK causing persistent induction of NFkappaB resulting in transactivation of HIV-1-LTR-regulated genes and induction of HIV-1 replication in infected T-cells Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.10 IKK
-
 Homo sapiens