Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Beltowski, J.; Marciniak, A.; Jamroz-Wisniewska, A.; Borkowska, E.; Wojcicka, G.
    Bidirectional regulation of renal cortical Na+,K+-ATPase by protein kinase C (2004), Acta Biochim. Pol., 51, 757-772.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.13 diacylglycerol
-
 Rattus norvegicus
2.7.11.13 mezerein stimulates classical, but not novel PKC isozymes Rattus norvegicus
2.7.11.13 phorbol 12,13-dibutyrate activates PKC, activates Na+,K+-ATPase activity at low concentration, but inhibits it at high concentration Rattus norvegicus
2.7.11.13 phorbol 12-myristate 13-acetate
-
 Rattus norvegicus
2.7.11.13 thymeleatoxin activates Na+,K+-ATPase activity at low concentration, but inhibits it at high concentration Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.13 GF109203X inhibits classical and novel, but not atypical PKC isozymes Rattus norvegicus
2.7.11.13 Gö-6976 inhibits classical, but not novel and atypical PKC isozymes Rattus norvegicus
2.7.11.13 LY333531 specific inhibition of PKCbeta Rattus norvegicus
2.7.11.13 phorbol 12,13-dibutyrate activates Na+,K+-ATPase activity at low concentration, but inhibits it at high concentration, the inhibitory effect can be reversed by preincubation with ethoxyresorufin, 17-octadecynoic acid, wortmannin, LY294002, cytochlasin D, or latrunculin B Rattus norvegicus
2.7.11.13 staurosporine inhibits all PKC isozymes Rattus norvegicus
2.7.11.13 thymeleatoxin activates Na+,K+-ATPase activity at low concentration, but inhibits it at high concentration Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.13 additional information Rattus norvegicus bidirectional regulation of renal cortical Na+,K+-ATPase by PKC ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.13 Rattus norvegicus
-
 male Wistar rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.13 kidney
-
 Rattus norvegicus
-
2.7.11.13 renal cortex
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.13 additional information bidirectional regulation of renal cortical Na+,K+-ATPase by PKC Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.13 PKC
-
 Rattus norvegicus