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Literature summary extracted from

  • Spencer, A.G.; Orita, S.; Malone, C.J.; Han, M.
    A RHO GTPase-mediated pathway is required during P cell migration in Caenorhabditis elegans (2001), Proc. Natl. Acad. Sci. USA, 98, 13132-13137.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.6.5.2 UNC-73 Trio-like guanine nucleotide exchange factor encoded by unc-73, acts as an activator of RHO-1 in the migration process, the UNC-73 GEF2 domain may have the exchange activity on RHO-1 in vivo Caenorhabditis elegans

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.5.2 T19N and G14V mutant rho-1 cDNA Caenorhabditis elegans

Protein Variants

EC Number Protein Variants Comment Organism
3.6.5.2 G14V constitutively active or gain of function Caenorhabditis elegans
3.6.5.2 additional information eliminating or reducing rho-1 gene function by using a dominant-negative transgene or dsRNA interference results in a severe defect in migration of hypodermal P cells to a ventral position Caenorhabditis elegans
3.6.5.2 T19N dominant negative mutation, phenotype Caenorhabditis elegans

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.5.2 N-(2-chlorobenzyl)-N-[[(4-methylphenyl)sulfonyl]carbamoyl]-L-alanine Rho toxin from Clostridium botulinum, ADP-ribosylates and specifically inactivates rho-1 Caenorhabditis elegans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.5.2 GTP + H2O Caenorhabditis elegans RHO-1 plays a role in hypodermal P cell migration to a ventral position during larval development GDP + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.5.2 Caenorhabditis elegans
-
 wild-type strain N2 Bristol
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.5.2 GTP + H2O
-
 Caenorhabditis elegans GDP + phosphate
-
 ?
3.6.5.2 GTP + H2O RHO-1 plays a role in hypodermal P cell migration to a ventral position during larval development Caenorhabditis elegans GDP + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.5.2 RHO-1 RhoA GTPase homologue Caenorhabditis elegans