Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Fritz, T.A.; Hurley, J.H.; Trinh, L.B.; Shiloach, J.; Tabak, L.A.
    The beginnings of mucin biosynthesis: the crystal structure of UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase-T1 (2004), Proc. Natl. Acad. Sci. USA, 101, 15307-15312.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.41 ppGaNTase-T1 (mppGaNTase-T1) is expressed as a fusion protein with maltose-binding protein at the N terminus and residues 42–559 of mppGaNTase-T1 at the C terminus separated by a tobacco etch virus protease recognition sequence. The fusion protein is expressed in Pichia pastoris Mus musculus

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.4.1.41 crystals of mppGaNTase-T1 (without maltose-binding protein) are grown by hanging drop vapor diffusion at room temperature Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.41 Mn2+ ion complexed by invariant D209 and H211 of the DXH motif and by invariant H344 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide Mus musculus initiates the formation of mucin-type, O-linked glycans by catalyzing the transfer of alpha-N-acetylgalactosamine from UDP-GalNAc to Ser or Thr residues of core proteins to form the Tn antigen (GalNAc-alpha-1-O-Ser/Thr) UDP + N-acetyl-D-galactosaminyl-polypeptide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.41 Mus musculus O08912
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.41
-
 Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide initiates the formation of mucin-type, O-linked glycans by catalyzing the transfer of alpha-N-acetylgalactosamine from UDP-GalNAc to Ser or Thr residues of core proteins to form the Tn antigen (GalNAc-alpha-1-O-Ser/Thr) Mus musculus UDP + N-acetyl-D-galactosaminyl-polypeptide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.41 pp-GaNTase
-
 Mus musculus
2.4.1.41 ppGaNTase-T1
-
 Mus musculus
2.4.1.41 UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase-T1
-
 Mus musculus