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Literature summary extracted from

  • Dutta, A.; Batra, J.; Pandey-Rai, S.; Singh, D.; Kumar, S.; Sen, J.
    Expression of terpenoid indole alkaloid biosynthetic pathway genes corresponds to accumulation of related alkaloids in Catharanthus roseus (L.) G. Don (2005), Planta, 220, 376-383.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.107 gene Dat, DNA sequence determination and analysis Catharanthus roseus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.107 acetyl-CoA + deacetylvindoline Catharanthus roseus last step in alkaloid vindoline biosynthesis, vindoline is reacted to vinblastine and vincristine, pathway overview CoA + vindoline
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 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.20 Catharanthus roseus O04847 Madagascar periwinkle
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2.3.1.107 Catharanthus roseus Q9ZTK5 cultivars Nirmal, Prabal, and Dhawal, the mutants gsr-3 and gsr-6, and 1 horticultural variety Pacifica blush
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.20 leaf
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 Catharanthus roseus
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1.14.11.20 root
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 Catharanthus roseus
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2.3.1.107 leaf
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 Catharanthus roseus
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2.3.1.107 additional information Dat gene expression profile analysis in cultivars Nirmal, Prabal, and Dhawal, the mutants gsr-3 and gsr-6, and 1 horticultural variety Pacifica blush, overview, not in root Catharanthus roseus
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2.3.1.107 seedling
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 Catharanthus roseus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.20 deacetoxyvindoline + 2-oxoglutarate + O2
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 Catharanthus roseus deacetylvindoline + succinate + CO2
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 ir
2.3.1.107 acetyl-CoA + deacetylvindoline
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 Catharanthus roseus CoA + vindoline
-
 ?
2.3.1.107 acetyl-CoA + deacetylvindoline last step in alkaloid vindoline biosynthesis, vindoline is reacted to vinblastine and vincristine, pathway overview Catharanthus roseus CoA + vindoline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.11.20 D4H
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 Catharanthus roseus
1.14.11.20 desacetoxyvindoline 4-hydroxylase
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 Catharanthus roseus
2.3.1.107 DAT
-
 Catharanthus roseus
2.3.1.107 deacetyl vindoline 4-O-acetyl transferase
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 Catharanthus roseus

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.107 acetyl-CoA
-
 Catharanthus roseus