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Literature summary extracted from

  • Lherbet, C.; Keillor, J.W.
    Probing the stereochemistry of the active site of gamma-glutamyl transpeptidase using sulfur derivatives of L-glutamic acid (2004), Org. Biomol. Chem., 2, 238-245.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.2.2 2-amino-4-(methylsulfinyl)butanoic acid competitive Rattus norvegicus
2.3.2.2 2-amino-4-(methylthio)butanoic acid competitive Rattus norvegicus
2.3.2.2 2-amino-4-cyanobutanoic acid
-
 Rattus norvegicus
2.3.2.2 2-amino-4-phosphonobutanoic acid competitive Rattus norvegicus
2.3.2.2 2-amino-4-sulfobutanoic acid uncompetitive Rattus norvegicus
2.3.2.2 2-amino-4-[(3-((carboxymethyl)amino)-3-oxopropyl)sulfinyl]butanoic acid
-
 Rattus norvegicus
2.3.2.2 2-aminopentanedioic acid competitive Rattus norvegicus
2.3.2.2 additional information no inhibition: 2-amino-3-(S-methylsulfonimidoyl)propanoic acid, 2-amino-4-(methylsulfonyl)butanoic acid, 5-hydroxy-DL-lysine Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.2.2 kidney
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.2 5-L-glutamyl-4-nitroanilide + glycylglycine
-
 Rattus norvegicus 4-nitroaniline + 5-L-glutamylglycylglycine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.2.2 gamma-glutamyl transpeptidase
-
 Rattus norvegicus
2.3.2.2 GGT
-
 Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.2.2 0.053
-
 2-amino-4-[(3-((carboxymethyl)amino)-3-oxopropyl)sulfinyl]butanoic acid
-
 Rattus norvegicus
2.3.2.2 5.9
-
 2-amino-4-(methylsulfinyl)butanoic acid pH 8.0, 37°C Rattus norvegicus
2.3.2.2 11.1
-
 2-amino-4-sulfobutanoic acid pH 8.0, 37°C Rattus norvegicus
2.3.2.2 14.1
-
 2-aminopentanedioic acid pH 8.0, 37°C Rattus norvegicus
2.3.2.2 20.6
-
 2-amino-4-cyanobutanoic acid pH 8.0, 37°C Rattus norvegicus
2.3.2.2 26.9
-
 2-amino-4-(methylthio)butanoic acid pH 8.0, 37°C Rattus norvegicus
2.3.2.2 35.8
-
 2-amino-4-phosphonobutanoic acid pH 8.0, 37°C Rattus norvegicus