EC Number | Application | Comment | Organism |
---|---|---|---|
1.14.13.9 | medicine | enzyme is a therapeutical target for treatment of Huntigton disease | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.13.9 | 3,4-dimethoxy-N-[4-(3-nitrophenyl)thiazol-2-yl]benzenesulfonamide | i.e. Ro 61-8048, high-affinity low molecular inhibitor | Saccharomyces cerevisiae | |
1.14.13.9 | Ro 61-8048 | high-affinity low molecular inhibitor | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.14.13.9 | mitochondrion | - |
Homo sapiens | 5739 | - |
1.14.13.9 | mitochondrion | - |
Saccharomyces cerevisiae | 5739 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.13.9 | L-kynurenine + NADPH + O2 | Homo sapiens | step in L-tryptophan catabolism, overview | 3-hydroxy-L-kynurenine + NADP+ + H2O | - |
? | |
1.14.13.9 | L-kynurenine + NADPH + O2 | Saccharomyces cerevisiae | step in L-tryptophan catabolism, overview | 3-hydroxy-L-kynurenine + NADP+ + H2O | - |
? | |
1.14.13.9 | additional information | Homo sapiens | the enzyme is a very potent suppressor of toxicity of a fragment of the protein huntingtin, Htt, which causes the neurodegenerative Huntington disease by aggregation in nuclear and cytoplasmic inclusion bodies | ? | - |
? | |
1.14.13.9 | additional information | Saccharomyces cerevisiae | the enzyme is a very potent suppressor of toxicity of a fragment of the protein huntingtin, Htt, which causes the neurodegenerative Huntington disease in humans by aggregation in nuclear and cytoplasmic inclusion bodies | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.13.9 | Homo sapiens | - |
- |
- |
1.14.13.9 | Saccharomyces cerevisiae | - |
diverse strains | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.13.9 | L-kynurenine + NADPH + O2 | - |
Homo sapiens | 3-hydroxy-L-kynurenine + NADP+ + H2O | - |
? | |
1.14.13.9 | L-kynurenine + NADPH + O2 | - |
Saccharomyces cerevisiae | 3-hydroxy-L-kynurenine + NADP+ + H2O | - |
? | |
1.14.13.9 | L-kynurenine + NADPH + O2 | step in L-tryptophan catabolism, overview | Homo sapiens | 3-hydroxy-L-kynurenine + NADP+ + H2O | - |
? | |
1.14.13.9 | L-kynurenine + NADPH + O2 | step in L-tryptophan catabolism, overview | Saccharomyces cerevisiae | 3-hydroxy-L-kynurenine + NADP+ + H2O | - |
? | |
1.14.13.9 | additional information | the enzyme is a very potent suppressor of toxicity of a fragment of the protein huntingtin, Htt, which causes the neurodegenerative Huntington disease by aggregation in nuclear and cytoplasmic inclusion bodies | Homo sapiens | ? | - |
? | |
1.14.13.9 | additional information | the enzyme is a very potent suppressor of toxicity of a fragment of the protein huntingtin, Htt, which causes the neurodegenerative Huntington disease in humans by aggregation in nuclear and cytoplasmic inclusion bodies | Saccharomyces cerevisiae | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.13.9 | Bna4 | - |
Homo sapiens |
1.14.13.9 | Bna4 | - |
Saccharomyces cerevisiae |
1.14.13.9 | KMO | - |
Homo sapiens |
1.14.13.9 | KMO | - |
Saccharomyces cerevisiae |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.14.13.9 | NADPH | - |
Homo sapiens | |
1.14.13.9 | NADPH | - |
Saccharomyces cerevisiae |