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Literature summary extracted from

  • Wu, R.F.; Liao, C.X.; Tomita, S.; Ichikawa, Y.; Terada, L.S.
    Porcine FAD-containing monooxygenase metabolizes lidocaine, bupivacaine and propranolol in vitro (2004), Life Sci., 75, 1011-1019.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.13.8 propranolol competitive, reaction with lidocaine or bupivacaine Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.13.8 0.143
-
 lidocaine pH 8.0, 25°C Sus scrofa
1.14.13.8 0.21
-
 propranolol pH 8.0, 25°C Sus scrofa
1.14.13.8 0.408
-
 bupivacaine pH 8.0, 25°C Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.8 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.13.8
-
 Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.13.8 liver
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.13.8 0.122
-
 activity with bupivacaine Sus scrofa
1.14.13.8 0.141
-
 activity with propranolol Sus scrofa
1.14.13.8 0.176
-
 activity with lidocaine Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.8 bupivacaine + NADPH + O2
-
 Sus scrofa bupivacaine-oxide + NADP+
-
 ?
1.14.13.8 lidocaine + NADPH + O2
-
 Sus scrofa lidocaine-oxide + NADP+
-
 ?
1.14.13.8 propranolol + NADPH + O2
-
 Sus scrofa propranolol-hydroxylamine + NADP+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.8 FAD
-
 Sus scrofa
1.14.13.8 NADPH
-
 Sus scrofa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.13.8 0.2
-
 propranolol pH 8.0, 25°C, inhibition of reaction with lidocaine Sus scrofa