Literature summary extracted from

MOrgan, B.; Dodds, D.R.; Zaks, A.; Andrews, D.R.; Klesse, R.
Enzymatic desymmetrization of prochiral 2-substituted-1,3-propanediols: A practical chemoenzymatic synthesis of a key precursor of SCH51048, a broad-spectrum orally active antifungal agent (1997), J. Org. Chem., 62, 7736-7743.

No PubMed abstract available

Application

EC Number	Application	Comment	Organism
3.1.1.3	synthesis	production of (S)-acetic acid 4-(2,4-difluoro-phenyl)-2-hydroxymethyl-pent-4-enyl ester, which is used as an improved azole antifungal. It shows activity against systemic Candida and pulmonary Aspergillus infections	Moesziomyces antarcticus

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.1.3	Moesziomyces antarcticus	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.1.1.3	2-[2-(2,4-difluoro-phenyl)-allyl]-propane-1,3-diol + vinyl acetate	-	Moesziomyces antarcticus	(S)-acetic acid 4-(2,4-difluoro-phenyl)-2-hydroxymethyl-pent-4-enyl ester + acetic acid 2-acetoxymethyl-4-(2,4-difluoro-phenyl)-pent-4-enyl-ester	-	?

Temperature Optimum [°C]

EC Number	Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
3.1.1.3	-	-	-	Moesziomyces antarcticus

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Release 2023.1 (January 2023)