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Literature summary extracted from

  • Galman, C.; Arvidsson, I.; Angelin, B.; Rudling, M.
    Monitoring hepatic cholesterol 7alpha-hydroxylase activity by assay of the stable bile acid intermediate 7alpha-hydroxy-4-cholesten-3-one in peripheral blood (2003), J. Lipid Res., 44, 859-866.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.23 microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.23 cholesterol + [reduced NADPH-hemoprotein reductase] + O2 Mus musculus first step of cholesterol catabolism, rate-limiting and major regulatory enzyme in the synthesis of bile acids 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.23 cholesterol + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens first step of cholesterol catabolism, rate-limiting and major regulatory enzyme in the synthesis of bile acids 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.23 cholesterol + [reduced NADPH-hemoprotein reductase] + O2 Rattus norvegicus first step of cholesterol catabolism, rate-limiting and major regulatory enzyme in the synthesis of bile acids 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.23 Homo sapiens
-
-
-
1.14.14.23 Mus musculus
-
-
-
1.14.14.23 Rattus norvegicus
-
 Sprague-Dawley rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.23 liver
-
 Mus musculus
-
1.14.14.23 liver
-
 Homo sapiens
-
1.14.14.23 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.23 cholesterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Mus musculus 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.23 cholesterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.23 cholesterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Rattus norvegicus 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.23 cholesterol + [reduced NADPH-hemoprotein reductase] + O2 first step of cholesterol catabolism, rate-limiting and major regulatory enzyme in the synthesis of bile acids Mus musculus 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.23 cholesterol + [reduced NADPH-hemoprotein reductase] + O2 first step of cholesterol catabolism, rate-limiting and major regulatory enzyme in the synthesis of bile acids Homo sapiens 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.23 cholesterol + [reduced NADPH-hemoprotein reductase] + O2 first step of cholesterol catabolism, rate-limiting and major regulatory enzyme in the synthesis of bile acids Rattus norvegicus 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.23 C7alphaOH
-
 Mus musculus
1.14.14.23 C7alphaOH
-
 Homo sapiens
1.14.14.23 C7alphaOH
-
 Rattus norvegicus
1.14.14.23 CYP7A1
-
 Mus musculus
1.14.14.23 CYP7A1
-
 Homo sapiens
1.14.14.23 CYP7A1
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.23 NADPH
-
 Mus musculus
1.14.14.23 NADPH
-
 Homo sapiens
1.14.14.23 NADPH
-
 Rattus norvegicus