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Literature summary extracted from

  • Lepine, J.; Bernard, O.; Plante, M.; Tetu, B.; Pelletier, G.; Labrie, F.; Belanger, A.; Guillemette, C.
    Specificity and regioselectivity of the conjugation of estradiol, estrone, and their catecholestrogen and methoxyestrogen metabolites by human uridine diphospho-glucuronosyltransferases expressed in endometrium (2004), J. Clin. Endocrinol. Metab., 89, 5222-5232.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.17 expression of UGT1A and UGT2B isozymes in HEK293 cells Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.17 additional information
-
 additional information different kinetic profiles of isozymes with different hormone substrates, overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 membrane
-
 Homo sapiens 16020
-
2.4.1.17 microsome
-
 Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.17 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.17 additional information Homo sapiens isozymes facilitate the excretion of estrogens to glucuronides, the most abundant estrogen conjugates ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens
-
 isozymes UGT1A1, UGT1A3, UGT1A8, UGT1A9, UGT1A10, and UGT2B7
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 uterine endometrium isozyme UGT2B7 Homo sapiens
-
2.4.1.17 uterus isozyme UGT2B7 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 4-hydroxyestrone + UDP-glucuronate
-
 Homo sapiens UDP + 4-hydroxyestrone-4-O-beta-D-glucuronide
-
 ?
2.4.1.17 additional information isozymes facilitate the excretion of estrogens to glucuronides, the most abundant estrogen conjugates Homo sapiens ?
-
 ?
2.4.1.17 UDP-glucuronate + 2-hydroxyestrone
-
 Homo sapiens UDP + 2-hydroxyestrone beta-D-glucuronide
-
 ?
2.4.1.17 UDP-glucuronate + 2-methoxyestrone
-
 Homo sapiens UDP + 2-methoxyestrone beta-D-glucuronide
-
 ?
2.4.1.17 UDP-glucuronate + 4-methoxyestrone
-
 Homo sapiens UDP + 4-methoxyestrone beta-D-glucuronide
-
 ?
2.4.1.17 UDP-glucuronate + estradiol
-
 Homo sapiens UDP + estradiol beta-D-glucuronide
-
 ?
2.4.1.17 UDP-glucuronate + estrone
-
 Homo sapiens UDP + estrone beta-D-glucuronide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.17 UGT
-
 Homo sapiens
2.4.1.17 uridine diphosphate glucuronosyltransferase
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.17 7.5
-
 assay at Homo sapiens