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Literature summary extracted from

  • Shia, W.J.; Osada, S.; Florens, L.; Swanson, S.K.; Washburn, M.P.; Workman, J.L.
    Characterization of the yeast trimeric-SAS acetyltransferase complex (2005), J. Biol. Chem., 280, 11987-11994.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.48 29000
-
 1 * 44000 + 1 * 75000 + 1 * 29000, the SAS complex consists of Sas2, Sas4 and Sas5, mass spectrometry analysis Saccharomyces cerevisiae
2.3.1.48 44000
-
 1 * 44000 + 1 * 75000 + 1 * 29000, the SAS complex consists of Sas2, Sas4 and Sas5, mass spectrometry analysis Saccharomyces cerevisiae
2.3.1.48 75000
-
 1 * 44000 + 1 * 75000 + 1 * 29000, the SAS complex consists of Sas2, Sas4 and Sas5, mass spectrometry analysis Saccharomyces cerevisiae
2.3.1.48 125000
-
-
 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.48 acetyl-CoA + histone H4 Saccharomyces cerevisiae exclusively acetylates of Lys16 of histone H4, the enzyme is required for bulk of H4 lysine 16 acetylation in vivo, role of SAS complex in antagonizing the speading of Sir proteins at silent loci in Saccharomyces cerevisiae CoA + acetylhistone H4
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.48 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.48 acetyl-CoA + histone H4 exclusively acetylates of Lys16 of histone H4, the enzyme is required for bulk of H4 lysine 16 acetylation in vivo, role of SAS complex in antagonizing the speading of Sir proteins at silent loci in Saccharomyces cerevisiae Saccharomyces cerevisiae CoA + acetylhistone H4
-
 ?
2.3.1.48 acetyl-CoA + histone H4 acetyltion of Lys16, acetylates free histones and weakly acetylates nucleosomes Saccharomyces cerevisiae CoA + acetylhistone H4
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.48 trimer 1 * 44000 + 1 * 75000 + 1 * 29000, the SAS complex consists of Sas2, Sas4 and Sas5, mass spectrometry analysis Saccharomyces cerevisiae

Synonyms

EC Number Synonyms Comment Organism
2.3.1.48 SAS complex
-
 Saccharomyces cerevisiae