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Literature summary extracted from

  • Bai, M.; Zhou, J.M.; Perrett, S.
    The yeast prion protein Ure2 shows glutathione peroxidase activity in both native and fibrillar forms (2004), J. Biol. Chem., 279, 50025-50030.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.11.1.9 GSH
-
 Saccharomyces cerevisiae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.11.1.9 2.1
-
 GSH pH 7.5, 25°C, reaction with H2O2 Saccharomyces cerevisiae
1.11.1.9 2.6
-
 GSH pH 7.5, 25°C, reaction with cumene hydroperoxide Saccharomyces cerevisiae
1.11.1.9 4.3
-
 H2O2 pH 7.5, 25°C Saccharomyces cerevisiae
1.11.1.9 5.5
-
 GSH pH 7.5, 25°C, reaction with tert-butyl hydroperoxide Saccharomyces cerevisiae
1.11.1.9 7.8
-
 cumene hydroperoxide pH 7.5, 25°C Saccharomyces cerevisiae
1.11.1.9 7.9
-
 tert-butyl hydroperoxide pH 7.5, 25°C Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
1.11.1.9 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.1.9 cumene hydroperoxide + GSH
-
 Saccharomyces cerevisiae 2-phenylpropan-2-ol + GSSG + H2O
-
 ?
1.11.1.9 H2O2 + GSH
-
 Saccharomyces cerevisiae H2O + GSSG
-
 ?
1.11.1.9 tert-butyl hydroperoxide + GSH
-
 Saccharomyces cerevisiae tert-butyl alcohol + GSSG + H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
1.11.1.9 More fibrillar aggregates show the same level of activity as native protein Saccharomyces cerevisiae

Synonyms

EC Number Synonyms Comment Organism
1.11.1.9 prion protein Ure2
-
 Saccharomyces cerevisiae
1.11.1.9 Ure2
-
 Saccharomyces cerevisiae

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.11.1.9 40
-
 reaction with cumene hydroperoxide Saccharomyces cerevisiae

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
1.11.1.9 25 45 25°C: about 40% of maximal activity, 45°C: about 40% of maximal activity Saccharomyces cerevisiae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.11.1.9 8
-
 reaction with cumene hydroperoxide Saccharomyces cerevisiae

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.11.1.9 7.5 9 pH 7.5: about 45% of maximal activity, pH 9.0: about 50% of maximal activity Saccharomyces cerevisiae

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.11.1.9 3.2
-
 GSH
-
 Saccharomyces cerevisiae