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Literature summary extracted from

  • Bennett, R.P.; Hassan, H.; Mandel, U.; Mirgorodskaya, E.; et al.
    Cloning of human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase that complements other GalNAc-transferases in complete O-glycosylation of the MUC1 tandem repeat (1998), J. Biol. Chem., 273, 30472-30481.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.41 expressed in Sf9 cells or in a stably transfected Chinese hamster ovary cell line exhibited a unique acceptor substrate specificity Homo sapiens
2.4.1.41 expressed in Sf9 cells, expressed in a stably transfected Chinese hamster ovary cell line exhibited a unique acceptor substrate specificity, expressed in High Five cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.4.1.41 additional information linkage analysis of GalNAc-T4 with the base pair G1516A substitution Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.41 0.01
-
 UDP-GalNAc
-
 Homo sapiens
2.4.1.41 0.01
-
 CPPTPSATTPAPPSSSAPPETTAA
-
 Homo sapiens
2.4.1.41 0.015
-
 CPPTPSATTPAPPSSSAPPETTAA
-
 Homo sapiens
2.4.1.41 0.029
-
 UDP-GalNAc
-
 Homo sapiens
2.4.1.41 0.04
-
 CPPTPSATTPAPPSSSAPPETTAA
-
 Homo sapiens
2.4.1.41 0.062
-
 UDP-GalNAc
-
 Homo sapiens
2.4.1.41 0.07
-
 DSTTPAPTTK
-
 Homo sapiens
2.4.1.41 0.16
-
 UDP-GalNAc determination of Km for UDP-GalNAc is performed with saturating concentration of CPPTPSATTPAPPSSSAPPETTAA as substrate. No incorporation is found with UDP-Gal or UDP-GlcNAc Homo sapiens
2.4.1.41 0.46
-
 DSTTPAPTTK
-
 Homo sapiens
2.4.1.41 0.48
-
 CPPTPSATTPAPPSSSAPPETTAA
-
 Homo sapiens
2.4.1.41 0.85
-
 DSTTPAPTTK
-
 Homo sapiens
2.4.1.41 2.19
-
 DSTTPAPTTK
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.41 Homo sapiens Q10471
-
-
2.4.1.41 Homo sapiens Q10472
-
-
2.4.1.41 Homo sapiens Q8N4A0
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.41
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.41 adrenal cortex Northern blot analysis of human tissues Homo sapiens
-
2.4.1.41 adrenal medulla Northern blot analysis of human tissues Homo sapiens
-
2.4.1.41 bone marrow Northern blot analysis of human tissues Homo sapiens
-
2.4.1.41 brain Northern blot analysis of human tissues Homo sapiens
-
2.4.1.41 colon Northern blot analysis of human tissues Homo sapiens
-
2.4.1.41 heart Northern blot analysis of human tissues Homo sapiens
-
2.4.1.41 intestine Northern blot analysis of human tissues Homo sapiens
-
2.4.1.41 kidney Northern blot analysis of human tissues Homo sapiens
-
2.4.1.41 leukocyte Northern blot analysis of human tissues Homo sapiens
-
2.4.1.41 liver Northern blot analysis of human tissues Homo sapiens
-
2.4.1.41 lung Northern blot analysis of human tissues Homo sapiens
-
2.4.1.41 lymph node Northern blot analysis of human tissues Homo sapiens
-
2.4.1.41 MKN-45 cell gastric carcinoma cell line Homo sapiens
-
2.4.1.41 MKN45 cell gastric carcinoma cell line Homo sapiens
-
2.4.1.41 additional information Northern analysis of human organs revealed a wide expression pattern Homo sapiens
-
2.4.1.41 muscle Northern blot analysis of human tissues Homo sapiens
-
2.4.1.41 ovary Northern blot analysis of human tissues Homo sapiens
-
2.4.1.41 pancreas Northern blot analysis of human tissues Homo sapiens
-
2.4.1.41 placenta Northern blot analysis of human tissues Homo sapiens
-
2.4.1.41 prostate gland Northern blot analysis of human tissues Homo sapiens
-
2.4.1.41 salivary gland immunohistology with a monoclonal antibody shows the expected Golgi-like localization in salivary glands Homo sapiens
-
2.4.1.41 small intestine Northern blot analysis of human tissues Homo sapiens
-
2.4.1.41 spleen Northern blot analysis of human tissues Homo sapiens
-
2.4.1.41 stomach Northern blot analysis of human tissues Homo sapiens
-
2.4.1.41 submandibular gland
-
 Homo sapiens
-
2.4.1.41 testis Northern blot analysis of human tissues Homo sapiens
-
2.4.1.41 thymus Northern blot analysis of human tissues Homo sapiens
-
2.4.1.41 thyroid gland Northern blot analysis of human tissues Homo sapiens
-
2.4.1.41 vermiform appendix Northern blot analysis of human tissues Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.41 5 UDP-N-acetyl-D-galactosamine + DSTTPAPTTK mucin derived substrate Homo sapiens 5 UDP + N-acetyl-D-galactosaminylated DSTTPAPTTK
-
 ?
2.4.1.41 5 UDP-N-acetyl-D-galactosamine + DSTTPAPTTK mucin derived substrate, acceptor substrate Homo sapiens 5 UDP + N-acetyl-D-galactosaminylated DSTTPAPTTK
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + Ac-CIRIQRGPGRAFVTIGKIGNMR
-
 Homo sapiens UDP + N-acetyl-D-galactosaminylated Ac-CIRIQRGPGRAFVTIGKIGNMR
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + Ac-PFVTHPGYD
-
 Homo sapiens UDP + N-acetyl-D-galactosaminylated Ac-PFVTHPGYD
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + Ac-QATEYEYLDYDFLPETEPPEM
-
 Homo sapiens UDP + N-acetyl-D-galactosaminylated Ac-QATEYEYLDYDFLPETEPPEM
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + Ac-QATEYEYLDYDFLPETEPPEM acceptor substrate Homo sapiens UDP + N-acetyl-D-galactosaminylated Ac-QATEYEYLDYDFLPETEPPEM
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + AHGVTSAPDTR
-
 Homo sapiens UDP + N-acetyl-D-galactosaminylated AHGVTSAPDTR
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + CPPTPSATTPAPPSSSAPPETTAA mucin derived substrate Homo sapiens UDP + N-acetyl-D-galactosaminylated CPPTPSATTPAPPSSSAPPETTAA
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + CPPTPSATTPAPPSSSAPPETTAA mucin derived substrate, acceptor substrate Homo sapiens UDP + N-acetyl-D-galactosaminylated CPPTPSATTPAPPSSSAPPETTAA
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + PRFQDSSSSKAPPPSLPSPSRLPG
-
 Homo sapiens UDP + N-acetyl-D-galactosaminylated PRFQDSSSSKAPPPSLPSPSRLPG
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + PTTTPISTTTMVTPTPTPTC mucin derived substrate Homo sapiens UDP + N-acetyl-D-galactosaminylated PTTTPISTTTMVTPTPTPTC
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + QATEYEYLDYDFLPEC
-
 Homo sapiens UDP + N-acetyl-D-galactosaminylated QATEYEYLDYDFLPEC
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + RPAPGSTAPPA
-
 Homo sapiens UDP + N-acetyl-D-galactosaminylated RPAPGSTAPPA
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + TAPPAHGVTSAPDTRPAPGSTAPP
-
 Homo sapiens UDP + N-acetyl-D-galactosaminylated TAPPAHGVTSAPDTRPAPGSTAPP
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + TAPPAHGVTSAPDTRPAPGSTAPP acceptor substrate Homo sapiens UDP + N-acetyl-D-galactosaminylated TAPPAHGVTSAPDTRPAPGSTAPP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.41 GalNAc-T1
-
 Homo sapiens
2.4.1.41 GalNAc-T2
-
 Homo sapiens
2.4.1.41 GalNAc-T3
-
 Homo sapiens
2.4.1.41 GalNAc-T4
-
 Homo sapiens
2.4.1.41 GalNAc-transferase
-
 Homo sapiens
2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase
-
 Homo sapiens