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Literature summary extracted from
- Biosynthesis of cholic acid in rat liver. 24-Hydroxylation of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid (1975), J. Biol. Chem., 250, 8243-8247.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.17.99.3 | ATP | required | Rattus norvegicus |  |
| 1.17.99.3 | GTP | stimulates to a lesser degree than ATP | Rattus norvegicus | |
| 1.17.99.3 | ITP | stimulates to a lesser degree than ATP | Rattus norvegicus | |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.17.99.3 | additional information | oxygen may be obligatory since there is almost complete inhibition when the reaction is performed in an atmosphere consisting of nitrogen | Rattus norvegicus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.17.99.3 | mitochondrion | - |
Rattus norvegicus | 5739 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.17.99.3 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.17.99.3 | liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.17.99.3 | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O + acceptor | conversion of the coenzyme A ester is lower than with the free acid as substrate | Rattus norvegicus | 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + reduced acceptor | - |
? | |
| 1.17.99.3 | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid + H2O + acceptor | - |
Rattus norvegicus | 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoic acid + reduced acceptor | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.17.99.3 | 7.5 | - |
- |
Rattus norvegicus |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.17.99.3 | 6.5 | 8.5 | pH 6.5: about 30% of maximal activity, pH 8.5: about 60% of maximal activity | Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.17.99.3 | coenzyme A | marked inhibition of reaction with 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid | Rattus norvegicus | |
| 1.17.99.3 | FMN | slight | Rattus norvegicus | |
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