Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Tiemann, B.; Depping, R.; Gineikiene, E.; Kaliniene, L.; Nivinskas, R.; Rueger, W.
    ModA and ModB, two ADP-ribosyltransferases encoded by bacteriophage T4: Catalytic properties and mutation analysis (2004), J. Bacteriol., 186, 7262-7272.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.2.30
-
 Tequatrovirus T4

Protein Variants

EC Number Protein Variants Comment Organism
2.4.2.30 E118A mutation reduces the toxicity of the enzyme and still allows small colonies to grow Tequatrovirus T4
2.4.2.30 E163A mutation reduces toxicity of ModA to a minor extent Tequatrovirus T4
2.4.2.30 E165A mutation in ModA reduces the toxicity to colony growth Tequatrovirus T4
2.4.2.30 E171A mutation reduces the toxicity of the enzyme and still allows small colonies to grow Tequatrovirus T4
2.4.2.30 E173A mutation largly abolishes enzyme activity Tequatrovirus T4
2.4.2.30 F127A mutation in ModA reduces the toxicity to colony growth Tequatrovirus T4
2.4.2.30 F129A mutation in ModA reduces the toxicity to colony growth Tequatrovirus T4
2.4.2.30 F129A mutation largly abolishes enzyme activity Tequatrovirus T4
2.4.2.30 I176A mutation reduces the toxicity of the enzyme and still allows small colonies to grow Tequatrovirus T4
2.4.2.30 L71A mutation largly abolishes enzyme activity Tequatrovirus T4
2.4.2.30 N128A mutation reduces toxicity of ModA to a minor extent Tequatrovirus T4
2.4.2.30 N130A mutant enzyme with toxicity close to that of wild-type enzyme Tequatrovirus T4
2.4.2.30 Q116A mutation reduces toxicity of ModA to a minor extent Tequatrovirus T4
2.4.2.30 Q164A mutation reduces toxicity of ModA to a minor extent Tequatrovirus T4
2.4.2.30 Q172A mutant enzyme with toxicity close to that of wild-type enzyme Tequatrovirus T4
2.4.2.30 R72A mutation in ModA reduces the toxicity to colony growth Tequatrovirus T4
2.4.2.30 R73A mutation largly abolishes enzyme activity Tequatrovirus T4
2.4.2.30 S109A mutation in ModA reduces the toxicity to colony growth Tequatrovirus T4
2.4.2.30 S111A mutant enzyme with toxicity close to that of wild-type enzyme Tequatrovirus T4
2.4.2.30 Y131A mutation largly abolishes enzyme activity Tequatrovirus T4

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.30 NAD+ + RNA polymerase Tequatrovirus T4 three ADP-ribosyltransferases, Alt, ModA, and ModB participate in the regulation of the T4 replication cycle by ADP-ribosylating a defined set of host proteins. ADP-ribosylation of RNA polymerase and of other host proteins allows initial phage-directed mRNA synthesis reactions to escape from host control nicotinamide + (ADP-D-ribosyl)-RNA polymerase
-
 ?
2.4.2.30 NAD+ + RNA polymerase Tequatrovirus T4 ModA three ADP-ribosyltransferases, Alt, ModA, and ModB participate in the regulation of the T4 replication cycle by ADP-ribosylating a defined set of host proteins. ADP-ribosylation of RNA polymerase and of other host proteins allows initial phage-directed mRNA synthesis reactions to escape from host control nicotinamide + (ADP-D-ribosyl)-RNA polymerase
-
 ?
2.4.2.30 NAD+ + RNA polymerase Tequatrovirus T4 ModB three ADP-ribosyltransferases, Alt, ModA, and ModB participate in the regulation of the T4 replication cycle by ADP-ribosylating a defined set of host proteins. ADP-ribosylation of RNA polymerase and of other host proteins allows initial phage-directed mRNA synthesis reactions to escape from host control nicotinamide + (ADP-D-ribosyl)-RNA polymerase
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.30 Tequatrovirus T4 P12726 ModA
-
2.4.2.30 Tequatrovirus T4 P12726 ModB
-
2.4.2.30 Tequatrovirus T4 ModA P12726 ModA
-
2.4.2.30 Tequatrovirus T4 ModB P12726 ModB
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.30
-
 Tequatrovirus T4

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.30 NAD+ + RNA polymerase
-
 Tequatrovirus T4 nicotinamide + (ADP-D-ribosyl)-RNA polymerase
-
 ?
2.4.2.30 NAD+ + RNA polymerase three ADP-ribosyltransferases, Alt, ModA, and ModB participate in the regulation of the T4 replication cycle by ADP-ribosylating a defined set of host proteins. ADP-ribosylation of RNA polymerase and of other host proteins allows initial phage-directed mRNA synthesis reactions to escape from host control Tequatrovirus T4 nicotinamide + (ADP-D-ribosyl)-RNA polymerase
-
 ?
2.4.2.30 NAD+ + RNA polymerase
-
 Tequatrovirus T4 ModA nicotinamide + (ADP-D-ribosyl)-RNA polymerase
-
 ?
2.4.2.30 NAD+ + RNA polymerase three ADP-ribosyltransferases, Alt, ModA, and ModB participate in the regulation of the T4 replication cycle by ADP-ribosylating a defined set of host proteins. ADP-ribosylation of RNA polymerase and of other host proteins allows initial phage-directed mRNA synthesis reactions to escape from host control Tequatrovirus T4 ModA nicotinamide + (ADP-D-ribosyl)-RNA polymerase
-
 ?
2.4.2.30 NAD+ + RNA polymerase
-
 Tequatrovirus T4 ModB nicotinamide + (ADP-D-ribosyl)-RNA polymerase
-
 ?
2.4.2.30 NAD+ + RNA polymerase three ADP-ribosyltransferases, Alt, ModA, and ModB participate in the regulation of the T4 replication cycle by ADP-ribosylating a defined set of host proteins. ADP-ribosylation of RNA polymerase and of other host proteins allows initial phage-directed mRNA synthesis reactions to escape from host control Tequatrovirus T4 ModB nicotinamide + (ADP-D-ribosyl)-RNA polymerase
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.30 ModA
-
 Tequatrovirus T4
2.4.2.30 ModB
-
 Tequatrovirus T4