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Literature summary extracted from

  • Burlingame, R.P.; Wyman, L.; Chapman, P.J.
    Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation (1986), J. Bacteriol., 168, 55-64.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.12.19 3-phenylpropionate + NADH + H+ + O2 Escherichia coli enables utilization of 3-phenylpropionate as carbon source 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD+
-
 ?
3.7.1.14 (2E,4Z)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O Escherichia coli the enzyme is involved in 3-phenylpropanoate catabolism (2E)-2-hydroxypenta-2,4-dienoate + succinate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.12.19 Escherichia coli
-
 and enzyme deficiency strains obtained from mutagenesis with ethylmethane sulfonate
-
1.14.13.127 no activity in Escherichia coli
-
-
-
1.14.13.127 no activity in Escherichia coli LW279
-
-
-
1.14.13.127 no activity in Escherichia coli LW303
-
-
-
3.7.1.14 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.12.19 3-phenylpropionate + NADH + H+ + O2
-
 Escherichia coli 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD+
-
 ?
1.14.12.19 3-phenylpropionate + NADH + H+ + O2 enables utilization of 3-phenylpropionate as carbon source Escherichia coli 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD+
-
 ?
3.7.1.14 (2E,4Z)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O
-
 Escherichia coli (2E)-2-hydroxypenta-2,4-dienoate + succinate
-
 ?
3.7.1.14 (2E,4Z)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O the enzyme is involved in 3-phenylpropanoate catabolism Escherichia coli (2E)-2-hydroxypenta-2,4-dienoate + succinate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.12.19 3-phenylpropionate dioxygenase
-
 Escherichia coli
1.14.12.19 Hca dioxygenase
-
 Escherichia coli
1.14.12.19 HcaA1A2CD
-
 Escherichia coli
3.7.1.14 MhpC
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.12.19 NADH
-
 Escherichia coli

Expression

EC Number Organism Comment Expression
3.7.1.14 Escherichia coli 3-(3-hydroxyphenyl)propionic acid, 3-(2-hydroxyphenyl)propionic acid, 3-(2,3-dihydroxyphenyl)propionic acid or hydrocinnamic acid or cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol are poor inducers up