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Literature summary extracted from

  • Hayward, D.; Wiid, I.; van Helden, P.
    Differential expression of mycothiol pathway genes: are they affected by antituberculosis drugs? (2004), IUBMB Life, 56, 131-138.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.8.1.15 medicine the enzyme is sensitive to free radical generating antituberculosis drugs and may be useful target for new drug development Mycobacterium tuberculosis variant bovis
3.5.1.103 medicine antisense oligonucleotides to GlcNAc-Ins deacetylase (Rv1170) mRNA affect mycobacterial growth. The enzyme is sensitive to free radical generating antituberculosis drugs and may be a useful targets for new drug development Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.1.15 mycothione + NADPH Mycobacterium tuberculosis variant bovis the enzyme is involved in mycothiol metabolism. Mycothiol may play an important role in the survival and adaption of mycobacteria to oxidative stress caused by normal metabolism, ir induced by the action of anti-tubercular drugs mycothiol + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.15 Mycobacterium tuberculosis variant bovis
-
-
-
3.5.1.103 Mycobacterium tuberculosis P9WJN3
-
-
3.5.1.103 Mycobacterium tuberculosis H37Rv P9WJN3
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.15 cell culture gene is actively transcribed during logarithmic growth Mycobacterium tuberculosis variant bovis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.15 mycothione + NADPH the enzyme is involved in mycothiol metabolism. Mycothiol may play an important role in the survival and adaption of mycobacteria to oxidative stress caused by normal metabolism, ir induced by the action of anti-tubercular drugs Mycobacterium tuberculosis variant bovis mycothiol + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.15 NADPH-dependent mycothiol reductase
-
 Mycobacterium tuberculosis variant bovis
3.5.1.103 GlcNAc-Ins deacetylase
-
 Mycobacterium tuberculosis
3.5.1.103 Rv1170
-
 Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.15 NADPH
-
 Mycobacterium tuberculosis variant bovis