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Literature summary extracted from

  • Itano, N.; Kimata, K.
    Mammalian hyaluronan synthases (2002), IUBMB Life, 54, 195-199.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.212
-
 Mus musculus
2.4.1.212 DNA and amino acid sequence determination and analysis, chromosome mapping of isozymes HAS1-3, genetic organization Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.4.1.212 additional information site-directed mutagenesis of residues of the cytoplasmic loop of isozyme HAS1 for determining the residues required for glycosyltransferase activity Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.212 plasma membrane
-
 Mus musculus 5886
-
2.4.1.212 plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.212 additional information Homo sapiens regulation mechanism of hyaluronan biosynthesis, stimulation of cells by cytokines effects the different expression patterns of the isoforms, especially during embryonic development, the isozymes have different roles in hyaluronan biosynthesis ?
-
 ?
2.4.1.212 additional information Mus musculus regulation mechanism of hyaluronan biosynthesis, stimulation of cells by cytokines effects the different expression patterns of the isoforms, especially during embryonic development, the isozymes have different roles in hyaluronan biosynthesis, isozymes exhibit different functions in tumor growth, progression, and determination of malignancy ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.212 Homo sapiens
-
 3 isozymes HAS1, HAS2, and HAS3 encoded by genes HAS1, HAS2, and HAS3
-
2.4.1.212 Mus musculus
-
 3 isozymes HAS1, HAS2, and HAS3 encoded by genes HAS1, HAS2, and HAS3
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.212 recombinant isozymes by immunoaffinity chromatography Mus musculus
2.4.1.212 recombinant isozymes by immunoaffinity chromatography Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.212 additional information regulation mechanism of hyaluronan biosynthesis, stimulation of cells by cytokines effects the different expression patterns of the isoforms, especially during embryonic development, the isozymes have different roles in hyaluronan biosynthesis Homo sapiens ?
-
 ?
2.4.1.212 additional information regulation mechanism of hyaluronan biosynthesis, stimulation of cells by cytokines effects the different expression patterns of the isoforms, especially during embryonic development, the isozymes have different roles in hyaluronan biosynthesis, isozymes exhibit different functions in tumor growth, progression, and determination of malignancy Mus musculus ?
-
 ?
2.4.1.212 additional information the isozymes form products of different size, HA synthesis modeling, active site and substrate binding site are located on the big cytoplasmic loop Mus musculus ?
-
 ?
2.4.1.212 additional information the isozymes form products of different size, HA synthesis modeling, active site and substrate binding site are located on the big cytoplasmic loop Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.1.212 More determination of isozyme structures with 7 putative transmembrane regions, 2 thereof at the N-terminus and 5 at the C-terminus, and a big cytoplasmic loop harboring the active site and the substrate binding site Mus musculus
2.4.1.212 More determination of isozyme structures with 7 putative transmembrane regions, thereof 2 at the N-terminus and 5 at the C-terminus, and a big cytoplasmic loop harboring the active site and the substrate binding site Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.4.1.212 HA synthase
-
 Mus musculus
2.4.1.212 HA synthase
-
 Homo sapiens
2.4.1.212 HAS
-
 Mus musculus
2.4.1.212 HAS
-
 Homo sapiens