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Literature summary extracted from

  • Joy, K.P.; Chaube, R.
    Catecholaminergic control of LH secretion: E2 modulation of tyrosine hydroxylase activity in female catfish Heteropneustes fossilis (2004), Fish Physiol. Biochem., 28, 33-35.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.16.2 estradiol-17beta biphasic effects on in vivo and in vitro enzyme activity and kinetics. Low concentrations (1 nM) stimulate, and high concentrations (1 mM) inhibit Heteropneustes fossilis

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.16.2 estradiol-17beta biphasic effects on in vivo and in vitro enzyme activity and kinetics. Low concentrations (1 nM) stimulate, and high concentrations (1 mM) inhibit Heteropneustes fossilis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.16.2 0.04
-
 L-tyrosine 30°C Heteropneustes fossilis
1.14.16.2 0.34
-
 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydropteridine 30°C Heteropneustes fossilis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.16.2 additional information Heteropneustes fossilis circulating titer of estradiol-17 beta can act differentially on the enzyme to alter catecholamineergic activity. Estradiol-17 beta may participate in the acute regulation of the enzyme by interacting with the cAMP signaling pathway ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.16.2 Heteropneustes fossilis
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.16.2 hypothalamus
-
 Heteropneustes fossilis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.16.2 L-tyrosine + 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydropteridine + O2
-
 Heteropneustes fossilis 3,4-dihydroxy-L-phenylalanine + ?
-
 ?
1.14.16.2 additional information circulating titer of estradiol-17 beta can act differentially on the enzyme to alter catecholamineergic activity. Estradiol-17 beta may participate in the acute regulation of the enzyme by interacting with the cAMP signaling pathway Heteropneustes fossilis ?
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.16.2 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydropteridine
-
 Heteropneustes fossilis