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Literature summary extracted from

  • Bachler, C.; Schneider, P.; Bahler, P.; Lustig, A.; Erni, B.
    Escherichia coli dihydroxyacetone kinase controls gene expression by binding to transcription factor DhaR (2005), EMBO J., 24, 283-293.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.29 additional information the DhaR transcription factor stimulates the transcription of the dhaKLM operon from a sigma70 promotor and autorepresses expression of DhaR Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.29 phosphoenolpyruvate + glycerone Escherichia coli regulation involving de-/phosphorylation, and the 3 subunits with ADP and transcription factor DhaR, overview pyruvate + glycerone phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.29 Escherichia coli P76015 subunit DhaK
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.29 phosphoenolpyruvate + glycerone
-
 Escherichia coli pyruvate + glycerone phosphate i.e. dihydroxyacetone phosphate ?
2.7.1.29 phosphoenolpyruvate + glycerone regulation involving de-/phosphorylation, and the 3 subunits with ADP and transcription factor DhaR, overview Escherichia coli pyruvate + glycerone phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.29 trimer enzyme exists of 3 subunit DhaK, DhaM, and DhaL: DhaK contains the dihydroxyacetone phosphate binding site, DhaL contains ADP as cofactor for phosphate double displacement from DhaM to dihydroxyacetone phosphate, and DhaM provides a phospho-histidine relay between phosphoenolpyruvate and DhaL-ADP Escherichia coli

Synonyms

EC Number Synonyms Comment Organism
2.7.1.29 DHA kinase
-
 Escherichia coli
2.7.1.29 dihydroxyacetone kinase
-
 Escherichia coli
2.7.1.29 More dihydroxyacetoe phosphate kinases exist in 2 different groups, one utilizing ATP as phosphate donor, the other utilizing phosphoenolpyrivate Escherichia coli
2.7.1.29 phosphoenolpyruvate carbohydrate phosphotransferase
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.29 ATP dependent on Escherichia coli